Cutting edge: crucial role of IL-1 and IL-23 in the innate IL-17 response of peripheral lymph node NK1.1- invariant NKT cells to bacteria. - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Journal of Immunology Année : 2011

Cutting edge: crucial role of IL-1 and IL-23 in the innate IL-17 response of peripheral lymph node NK1.1- invariant NKT cells to bacteria.

Jean-Marc Doisne
Valérie Soulard
Chantal Bécourt
  • Fonction : Auteur
Latiffa Amniai
  • Fonction : Auteur
Pauline Henrot
  • Fonction : Auteur
Colin Havenar-Daughton
  • Fonction : Auteur
Charlène Blanchet
  • Fonction : Auteur
Bernhard Ryffel
  • Fonction : Auteur
  • PersonId : 841831
Julien C Marie
Isabelle Couillin
  • Fonction : Auteur
  • PersonId : 931092
Kamel Benlagha
  • Fonction : Auteur

Résumé

We have shown previously that peripheral lymph node-resident retinoic acid receptor-related orphan receptor γt(+) NK1.1(-) invariant NKT (iNKT) cells produce IL-17A independently of IL-6. In this study, we show that the concomitant presence of IL-1 and IL-23 is crucial to induce a rapid and sustained IL-17A/F and IL-22 response by these cells that requires TCR-CD1d interaction and partly relies on IL-23-mediated upregulation of IL-23R and IL-1R1 expression. We further show that IL-1 and IL-23 produced by pathogen-associated molecular pattern-stimulated dendritic cells induce this response from NK1.1(-) iNKT cells in vitro, involving mainly TLR2/4-signaling pathways. Finally, we found that IL-17A production by these cells occurs very early and transiently in vivo in response to heat-killed bacteria. Overall, our study indicates that peripheral lymph node NK1.1(-) iNKT cells could be a source of innate Th17-related cytokines during bacterial infections and supports the hypothesis that they are able to provide an efficient first line of defense against bacterial invasion.

Domaines

Immunologie

Dates et versions

hal-00591927 , version 1 (10-05-2011)

Identifiants

Citer

Jean-Marc Doisne, Valérie Soulard, Chantal Bécourt, Latiffa Amniai, Pauline Henrot, et al.. Cutting edge: crucial role of IL-1 and IL-23 in the innate IL-17 response of peripheral lymph node NK1.1- invariant NKT cells to bacteria.. Journal of Immunology, 2011, 186 (2), pp.662-6. ⟨10.4049/jimmunol.1002725⟩. ⟨hal-00591927⟩
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