In this paper we apply the methods of homogenization to the full Navier-Stokes-Fourier system describing the motion of a general viscous, compressible, and heat conducting fluid. We study the asymptotic behavior of solutions in perforated domains with tiny holes, where the diameter of the holes is proportional to their mutual distance. As a limit system, we identify a porous medium type equation with a nonlinear Darcy's law.