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            <title xml:lang="en">Gastrointestinal transit, post prandial lipemia and satiety following three days high-fat diet in men</title>
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                <title xml:lang="en">Gastrointestinal transit, post prandial lipemia and satiety following three days high-fat diet in men</title>
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                <title level="j">European Journal of Clinical Nutrition</title>
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                <term xml:lang="en">gastric emptying</term>
                <term xml:lang="en">lipemia</term>
                <term xml:lang="en">mouth to caecum transit time</term>
                <term xml:lang="en">satiety</term>
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              <p>Background: High fat diets of two weeks have been shown to accelerate gastric emptying (GE). To date no studies have shown any alteration in GE following shorter HF diets. Objective: To assess if a high-fat, high-energy (HF) diet of three days can adapt gastrointestinal (GI) transit, blood lipids and satiety. Methods: Eleven male volunteers participated in a study consisting of three, three-day interventions each separated by a test day. During the first intervention volunteers recorded their diet. In the second and third interventions volunteers repeated their food diary plus either a low-fat (LF) yogurt or HF yogurt supplement in randomized order. Test days involved measurement of GE using the 13C OBT, mouth-to-caecum transit time (MCTT) using the inulin H2 breath test and satiety using visual analogue scales. Blood samples for measurement of lipaemia were taken using venous cannula. Results: MCTT was different between the three test days (p=0.038) with the shortest MCTT following the HF intervention. GE was shortest following the HF intervention. There were no differences in satiety between the interventions. The HF intervention reduced triglycerides, total cholesterol and LDL cholesterol and increased HDL cholesterol. Conclusion: This study shows that changes in GI transit due to a HF diet can occur in a time period as short as three days.</p>
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