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Article Dans Une Revue European Journal of Clinical Microbiology and Infectious Diseases Année : 2010

Emergence of a colistin-resistant KPC-2-producing ST258 clone in Hungary

Á. Tóth
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E. Puskás
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L. Jánvári
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M. Farkas
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A. Dobák
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K. Böröcz
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J. Pászti
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Résumé

Nine isolates showing non-susceptibility to carbapenems were collected from three centres in the north-eastern region of Hungary. The minimum inhibitory concentrations (MICs) of antibiotics were determined by Etest. The putative production of a carbapenemase was tested by the modified Hodge test. The presence of genes was verified by polymerase chain reaction (PCR) and sequencing. Furthermore, molecular typing was performed by pulsed-field gel electrophoresis (PFGE) and multilocus sequence typing (MLST). All isolates showed extensively drug-resistant (XDR) phenotype, and of these, eight isolates were highly resistant to colistin. The isolates carried , , and . PFGE analysis of the nine KPC-2-producing Hungarian ST258 isolates, two KPC-2-producing Norwegian ST258 isolates and 33 CTX-M-15-producing ST11 isolates revealed the existence of one genetic cluster at an 88% similarity level. The overall results of the PFGE clustering, MLST and the presence of SHV-11 in both ST11 and ST258 suggest that this is the first hyperepidemic clonal complex of multidrug-resistant , probably CC258/CC340, possibly undergoing worldwide spread.

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Dates et versions

hal-00586597 , version 1 (18-04-2011)

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Á. Tóth, I. Damjanova, E. Puskás, L. Jánvári, M. Farkas, et al.. Emergence of a colistin-resistant KPC-2-producing ST258 clone in Hungary. European Journal of Clinical Microbiology and Infectious Diseases, 2010, 29 (7), pp.765-769. ⟨10.1007/s10096-010-0921-3⟩. ⟨hal-00586597⟩

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