Characterisation of qnr plasmid-mediated quinolone resistance in Enterobacteriaceae from Italy: association of the qnrB19 allele with the integron element ISCR1 in Escherichia coli - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue International Journal of Antimicrobial Agents Année : 2010

Characterisation of qnr plasmid-mediated quinolone resistance in Enterobacteriaceae from Italy: association of the qnrB19 allele with the integron element ISCR1 in Escherichia coli

Sara N. Richter
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Cristina Bergo
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Antonietta Cavallaro
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Résumé

The spread of plasmid-mediated quinolone resistance determinants (-like determinants) was evaluated in a collection of 232 ciprofloxacin-resistant or extended-spectrum β-lactamase (ESBL)-producing enterobacterial isolates recovered between November 2007 and May 2008 at Padua University Hospital, Italy. genes were mainly found in (68%) and to a lesser extent in (5.1%). Among the , and alleles found, the latter was by far the most frequent. Genetic environment analysis revealed that one gene in was embedded in an IS complex class 1 integron. All other genes were flanked by an IS region as part of the Tn transposon. and containing strains were not clonally related. Both topoisomerase II mutations and ESBL (mainly SHV-12, TEM-1 and TEM-150 types) were present in most of the -positive strains. is extremely frequent in isolates from Italy. In addition, association of with the IS mobile element in suggests a broad distribution of this resistance gene in the near future.
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hal-00585826 , version 1 (14-04-2011)

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Sara N. Richter, Ilaria Frasson, Cristina Bergo, Riccardo Manganelli, Antonietta Cavallaro, et al.. Characterisation of qnr plasmid-mediated quinolone resistance in Enterobacteriaceae from Italy: association of the qnrB19 allele with the integron element ISCR1 in Escherichia coli. International Journal of Antimicrobial Agents, 2010, 35 (6), pp.578. ⟨10.1016/j.ijantimicag.2010.02.015⟩. ⟨hal-00585826⟩

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