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Article Dans Une Revue European Journal of Clinical Nutrition Année : 2010

Inverse relation between vitamin D and serum total IgG in the Scandinavian Cystic Fibrosis Nutritional Study

Résumé

Background/Objectives: The hallmark of cystic fibrosis (CF) is chronic lung inflammation. The severity of lung disease is closely correlated with IgG levels. Beyond its contribution to the bone health, the importance of vitamin D has not been fully recognized due to lack of human studies providing evidence of its benefit. In context of the recently described immunomodulatory functions of vitamin D, we aimed to assess the relationship between vitamin D and IgG levels. Subjects/Methods: 896 CF patients were included (0.53 - 65.9 years) from 7 centers in Denmark, Norway and Sweden. Serum 25-hydroxyvitamin D (25OHD) and total IgG were measured, spirometry was carried out and vitamin D intake data were gathered using a seven-day dietary food record. Multiple linear regression analyses were performed for IgG and FEV1 as dependent variables, and serum 25OHD, daily food and supplemented vitamin D sources of intake as independent variables. The model was controlled for age, gender, genotype, CF-related diabetes, season, infection/colonization status, long-term oral corticosteroid treatment, long-term treatment with macrolide antibiotics, pancreatic insufficient phenotype and Body Mass Index z-score. Results: Serum total IgG levels were negatively associated with serum 25OHD (adjusted R2=0.376; beta=-0.02; p<0.001), supplemented vitamin D intake per kg bodyweight (adj.R2=0.375; beta=-0.82; p<0.001), and total vitamin D intake per kg bodyweight (adj.R2=0.398; beta=-0.60; p=0.002). Serum 25OHD was positively associated with FEV1 (adj.R2=0.308; beta=0.0007; p=0.025). Conclusions: Increasing vitamin D intake may positively modulate inflammation in CF. The study supports the proposed role of vitamin D in the immune system during infection and substantiates prospective studies.
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hal-00578708 , version 1 (22-03-2011)

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Terezia Pincikova, Kristina Nilsson, Inger Elisabeth Moen, Ferenc Karpati, Gjermund Fluge, et al.. Inverse relation between vitamin D and serum total IgG in the Scandinavian Cystic Fibrosis Nutritional Study. European Journal of Clinical Nutrition, 2010, ⟨10.1038/ejcn.2010.194⟩. ⟨hal-00578708⟩

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