A 100 MHz high resolution ultrasonic micro-transducer with a focal lens is designed for medical imaging based on monocrystalline lithium niobate (LiNbO 3 ) 36°/Y-cut. Finite element analysis is used to characterize the impulse response of this transducer and the stationary wave propagation. The results show that the focal lens attributes a lot to the directivity and the resolution. The wave derived by LiNbO 3 36°/Y-cut element demonstrates a better property compared with ZnO. The energy of transmitted wave at the focus is increased by 16.53% and 314.7% due to LiNbO 3 and the matching layers, respectively.