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            <title xml:lang="en">Purification, characterisation and identification of acidocin LCHV, an antimicrobial peptide produced by n.v. Er 317/402 strain Narine</title>
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                <title xml:lang="en">Purification, characterisation and identification of acidocin LCHV, an antimicrobial peptide produced by n.v. Er 317/402 strain Narine</title>
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              <p>In the last two decades, antimicrobial peptides (AMPs) have been gaining attention as antimicrobial alternatives to chemical food preservatives and commonly used antibiotics. n.v. Er 317/402 strain Narine produces a small AMP with a molecular weight of 1.1kDa, designated acidocin LCHV. In this study, the AMP was extremely heat stable (90min at 130°C), was active over a wide pH range and was found to be sensitive to proteolytic enzymes (trypsin, pepsin and proteinase K). Acidocin LCHV has a broad spectrum of activity both against Gram-positive and Gram-negative pathogens, including several that are classified as Especially Dangerous Infections by the World Health Organization as well as meticillin-resistant (MRSA) and . Matrix-assisted laser desorption/ionisation time-of-flight mass spectrometry (MALDI-TOF/MS) was used to determine the molecular mass and sequence of the purified peptide. Complete killing with immediate impact on cells was observed within a very short period of time (10min).</p>
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