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Article Dans Une Revue Amino Acids Année : 2009

Process improvement in amino acids N-carboxyanhydride synthesis by N-carbamoyl amino acid

Résumé

Amino acid N-carboxyanhydrides (NCA), convenient monomer for polypeptide synthesis, are easily prepared in high purity as the result of N-carbamoyl amino acids (CAA) nitrosation by gaseous NOx (4:1 NO + O2 mixture, or NOCl) in toluene. Removal of polar side products is then efficiently carried out during subsequent work-up and crystallisation so that the resulting NCA obtained in good yield is suitable for controlled, primary amine-initiated polymerisation.

Domaines

Chimie organique
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Dates et versions

hal-00554687 , version 1 (11-01-2011)

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Citer

Olivier Lagrille, Grégoire Danger, Laurent Boiteau, Jean-Christophe Rossi, Jacques Taillades. Process improvement in amino acids N-carboxyanhydride synthesis by N-carbamoyl amino acid. Amino Acids, 2009, 36, pp.341-347. ⟨10.1007/s00276-008-0090-1⟩. ⟨hal-00554687⟩
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