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Conference Papers Year : 2010

Modeling spatio-temporal processing in cerebellar granular layer and effects of controlled inhibition

Sathyaa Subramaniyam
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Chaitanya Medini
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Bipin Nair
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Shyam Diwakar
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Abstract

The cerebellum input stage has been known to perform spatio-temporal transformations and combinatorial operations [1] [2] on input signals. In this paper, we developed a model to study information transmission and signal recoding in the cerebellar granular layer and to test observations like center-surround organization and time-window hypothesis [1] [3]. Detailed biophysical models were used to study synaptic plasticity and its effect in generation and modulation of spikes in the granular layer network. Our results indicated that spatio-temporal information transfer through the granular network is controlled by synaptic inhibition [1]. Spike amplitude and number of spikes were modulated by LTP and LTD. Both in vitro and in vivo simulations indicated that inhibitory input via Golgi cells acts as a modulator and regulates the post synaptic excitability.
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Dates and versions

hal-00553408 , version 1 (10-03-2011)

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  • HAL Id : hal-00553408 , version 1

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Sathyaa Subramaniyam, Chaitanya Medini, Bipin Nair, Shyam Diwakar. Modeling spatio-temporal processing in cerebellar granular layer and effects of controlled inhibition. Cinquième conférence plénière française de Neurosciences Computationnelles, "Neurocomp'10", Aug 2010, Lyon, France. ⟨hal-00553408⟩

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