<?xml version="1.0" encoding="utf-8"?>
<TEI xmlns="http://www.tei-c.org/ns/1.0" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:hal="http://hal.archives-ouvertes.fr/" xmlns:gml="http://www.opengis.net/gml/3.3/" xmlns:gmlce="http://www.opengis.net/gml/3.3/ce" version="1.1" xsi:schemaLocation="http://www.tei-c.org/ns/1.0 http://api.archives-ouvertes.fr/documents/aofr-sword.xsd">
  <teiHeader>
    <fileDesc>
      <titleStmt>
        <title>HAL TEI export of hal-00552701</title>
      </titleStmt>
      <publicationStmt>
        <distributor>CCSD</distributor>
        <availability status="restricted">
          <licence target="https://creativecommons.org/publicdomain/zero/1.0/">CC0 1.0 - Universal</licence>
        </availability>
        <date when="2026-05-01T23:47:20+02:00"/>
      </publicationStmt>
      <sourceDesc>
        <p part="N">HAL API Platform</p>
      </sourceDesc>
    </fileDesc>
  </teiHeader>
  <text>
    <body>
      <listBibl>
        <biblFull>
          <titleStmt>
            <title xml:lang="en">Addition of pathology and biomarker information significantly improves the performance of the Manchester scoring system for BRCA1 and BRCA2 testing</title>
            <author role="crp">
              <persName>
                <forename type="first">D Gareth R</forename>
                <surname>Evans</surname>
              </persName>
              <email type="md5">8024bc164f10950fd5fdefb9e5a8c5d0</email>
              <email type="domain">cmmc.nhs.uk</email>
              <idno type="idhal" notation="numeric">887782</idno>
              <idno type="halauthorid" notation="string">521494-887782</idno>
              <affiliation ref="#struct-138419"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Fiona</forename>
                <surname>Lalloo</surname>
              </persName>
              <email type="md5">d9e29e4a97a85fce1a0e1cc7e17ddfb5</email>
              <email type="domain">cmmc.nhs.uk</email>
              <idno type="idhal" notation="numeric">887783</idno>
              <idno type="halauthorid" notation="string">521495-887783</idno>
              <affiliation ref="#struct-138420"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Angela</forename>
                <surname>Cramer</surname>
              </persName>
              <email type="md5">d5d03b402d162b9096288a9eb49f84d3</email>
              <email type="domain">christie.nhs.uk</email>
              <idno type="idhal" notation="numeric">887784</idno>
              <idno type="halauthorid" notation="string">521496-887784</idno>
              <affiliation ref="#struct-138421"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Elizabeth</forename>
                <surname>Jones</surname>
              </persName>
              <email type="md5">6b5034f7c516d965ce42d644a226e254</email>
              <email type="domain">cmft.nhs.uk</email>
              <idno type="idhal" notation="numeric">887785</idno>
              <idno type="halauthorid" notation="string">521497-887785</idno>
              <affiliation ref="#struct-138422"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Fiona</forename>
                <surname>Knox</surname>
              </persName>
              <email type="md5">870299b37facd0a11e8ffa3062235fb0</email>
              <email type="domain">uhsm.nhs.uk</email>
              <idno type="idhal" notation="numeric">887786</idno>
              <idno type="halauthorid" notation="string">521498-887786</idno>
              <affiliation ref="#struct-138423"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Eitan</forename>
                <surname>Amir</surname>
              </persName>
              <email type="md5">1a1f8b4fc9b5d7df11564bf65197860f</email>
              <email type="domain">doctors.org</email>
              <idno type="idhal" notation="numeric">887787</idno>
              <idno type="halauthorid" notation="string">521499-887787</idno>
              <affiliation ref="#struct-138424"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Anthony</forename>
                <surname>Howell</surname>
              </persName>
              <email type="md5">b41a0c9e65458603211096fbb8b460ae</email>
              <email type="domain">christie.nhs.uk</email>
              <idno type="idhal" notation="numeric">887788</idno>
              <idno type="halauthorid" notation="string">521500-887788</idno>
              <affiliation ref="#struct-138421"/>
            </author>
            <editor role="depositor">
              <persName>
                <forename>Hal</forename>
                <surname>Peer</surname>
              </persName>
              <email type="md5">8d58fc1b670b8074dd83e4a4c93d5914</email>
              <email type="domain">inria.fr</email>
            </editor>
          </titleStmt>
          <editionStmt>
            <edition n="v1" type="current">
              <date type="whenSubmitted">2011-01-06 04:24:47</date>
              <date type="whenWritten">2009-03-15</date>
              <date type="whenModified">2025-01-08 21:26:03</date>
              <date type="whenReleased">2011-01-06 04:24:47</date>
              <date type="whenProduced">2009-12-01</date>
              <date type="whenEndEmbargoed">2011-01-06</date>
              <ref type="file" target="https://hal.science/hal-00552701v1/document">
                <date notBefore="2011-01-06"/>
              </ref>
              <ref type="file" subtype="author" n="1" target="https://hal.science/hal-00552701v1/file/PEER_stage2_10.1136%252Fjmg.2009.067850.pdf" id="file-552701-539403">
                <date notBefore="2011-01-06"/>
              </ref>
              <ref type="externalLink" target="https://hal.archives-ouvertes.fr/hal-00552701/document"/>
            </edition>
            <respStmt>
              <resp>contributor</resp>
              <name key="148147">
                <persName>
                  <forename>Hal</forename>
                  <surname>Peer</surname>
                </persName>
                <email type="md5">8d58fc1b670b8074dd83e4a4c93d5914</email>
                <email type="domain">inria.fr</email>
              </name>
            </respStmt>
          </editionStmt>
          <publicationStmt>
            <distributor>CCSD</distributor>
            <idno type="halId">hal-00552701</idno>
            <idno type="halUri">https://hal.science/hal-00552701</idno>
            <idno type="halBibtex">evans:hal-00552701</idno>
            <idno type="halRefHtml">&lt;i&gt;Journal of Medical Genetics&lt;/i&gt;, 2009, 46 (12), pp.811. &lt;a target="_blank" href="https://dx.doi.org/10.1136/jmg.2009.067850"&gt;&amp;#x27E8;10.1136/jmg.2009.067850&amp;#x27E9;&lt;/a&gt;</idno>
            <idno type="halRef">Journal of Medical Genetics, 2009, 46 (12), pp.811. &amp;#x27E8;10.1136/jmg.2009.067850&amp;#x27E9;</idno>
            <availability status="restricted">
              <licence target="https://about.hal.science/hal-authorisation-v1/">HAL Authorization<ref corresp="#file-552701-539403"/></licence>
            </availability>
          </publicationStmt>
          <seriesStmt>
            <idno type="stamp" n="PEER">PEER Publishing and the Ecology of European Research</idno>
          </seriesStmt>
          <notesStmt>
            <note type="audience" n="2">International</note>
            <note type="popular" n="0">No</note>
            <note type="peer" n="1">Yes</note>
          </notesStmt>
          <sourceDesc>
            <biblStruct>
              <analytic>
                <title xml:lang="en">Addition of pathology and biomarker information significantly improves the performance of the Manchester scoring system for BRCA1 and BRCA2 testing</title>
                <author role="crp">
                  <persName>
                    <forename type="first">D Gareth R</forename>
                    <surname>Evans</surname>
                  </persName>
                  <email type="md5">8024bc164f10950fd5fdefb9e5a8c5d0</email>
                  <email type="domain">cmmc.nhs.uk</email>
                  <idno type="idhal" notation="numeric">887782</idno>
                  <idno type="halauthorid" notation="string">521494-887782</idno>
                  <affiliation ref="#struct-138419"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Fiona</forename>
                    <surname>Lalloo</surname>
                  </persName>
                  <email type="md5">d9e29e4a97a85fce1a0e1cc7e17ddfb5</email>
                  <email type="domain">cmmc.nhs.uk</email>
                  <idno type="idhal" notation="numeric">887783</idno>
                  <idno type="halauthorid" notation="string">521495-887783</idno>
                  <affiliation ref="#struct-138420"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Angela</forename>
                    <surname>Cramer</surname>
                  </persName>
                  <email type="md5">d5d03b402d162b9096288a9eb49f84d3</email>
                  <email type="domain">christie.nhs.uk</email>
                  <idno type="idhal" notation="numeric">887784</idno>
                  <idno type="halauthorid" notation="string">521496-887784</idno>
                  <affiliation ref="#struct-138421"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Elizabeth</forename>
                    <surname>Jones</surname>
                  </persName>
                  <email type="md5">6b5034f7c516d965ce42d644a226e254</email>
                  <email type="domain">cmft.nhs.uk</email>
                  <idno type="idhal" notation="numeric">887785</idno>
                  <idno type="halauthorid" notation="string">521497-887785</idno>
                  <affiliation ref="#struct-138422"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Fiona</forename>
                    <surname>Knox</surname>
                  </persName>
                  <email type="md5">870299b37facd0a11e8ffa3062235fb0</email>
                  <email type="domain">uhsm.nhs.uk</email>
                  <idno type="idhal" notation="numeric">887786</idno>
                  <idno type="halauthorid" notation="string">521498-887786</idno>
                  <affiliation ref="#struct-138423"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Eitan</forename>
                    <surname>Amir</surname>
                  </persName>
                  <email type="md5">1a1f8b4fc9b5d7df11564bf65197860f</email>
                  <email type="domain">doctors.org</email>
                  <idno type="idhal" notation="numeric">887787</idno>
                  <idno type="halauthorid" notation="string">521499-887787</idno>
                  <affiliation ref="#struct-138424"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Anthony</forename>
                    <surname>Howell</surname>
                  </persName>
                  <email type="md5">b41a0c9e65458603211096fbb8b460ae</email>
                  <email type="domain">christie.nhs.uk</email>
                  <idno type="idhal" notation="numeric">887788</idno>
                  <idno type="halauthorid" notation="string">521500-887788</idno>
                  <affiliation ref="#struct-138421"/>
                </author>
              </analytic>
              <monogr>
                <idno type="halJournalId" status="VALID">21893</idno>
                <idno type="issn">0022-2593</idno>
                <idno type="eissn">1468-6244</idno>
                <title level="j">Journal of Medical Genetics</title>
                <imprint>
                  <publisher>BMJ Publishing Group</publisher>
                  <biblScope unit="volume">46</biblScope>
                  <biblScope unit="issue">12</biblScope>
                  <biblScope unit="pp">811</biblScope>
                  <date type="datePub">2009-12-01</date>
                </imprint>
              </monogr>
              <idno type="doi">10.1136/jmg.2009.067850</idno>
            </biblStruct>
          </sourceDesc>
          <profileDesc>
            <langUsage>
              <language ident="en">English</language>
            </langUsage>
            <textClass>
              <keywords scheme="author">
                <term xml:lang="en">Diagnostics tests</term>
                <term xml:lang="en">Guidelines</term>
                <term xml:lang="en">Obstetrics and Gynaecology</term>
                <term xml:lang="en">Cancer: breast</term>
                <term xml:lang="en">Genetic epidemiology</term>
              </keywords>
              <classCode scheme="halTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halOldTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halTreeTypology" n="ART">Journal articles</classCode>
            </textClass>
            <abstract xml:lang="en">
              <p>Selection for genetic testing of BRCA1/BRCA2 is an important area of healthcare. Whilst testing costs for mutational analysis are falling, costs in North America remains in excess of US $3,000 (UK price can be £690). Guidelines in most countries use a 10-20% threshold of detecting a mutation in BRCA1/2 combined within a family before mutational analysis is considered. A number of computer based models have been developed. However, use of these models can be time consuming and difficult to use. The Manchester scoring system was developed in 2003 to simplify the selection process without losing accuracy.</p>
            </abstract>
          </profileDesc>
        </biblFull>
      </listBibl>
    </body>
    <back>
      <listOrg type="structures">
        <org type="laboratory" xml:id="struct-138419" status="INCOMING">
          <orgName>St Mary's Manchester</orgName>
          <desc>
            <address>
              <country key="GB"/>
            </address>
          </desc>
          <listRelation>
            <relation active="#struct-333833" type="direct"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-138420" status="INCOMING">
          <orgName>St Marys Hospital, Manchester</orgName>
          <desc>
            <address>
              <country key="GB"/>
            </address>
          </desc>
          <listRelation>
            <relation active="#struct-333834" type="direct"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-138421" status="INCOMING">
          <orgName>The Christie</orgName>
          <desc>
            <address>
              <country key="GB"/>
            </address>
          </desc>
          <listRelation>
            <relation active="#struct-328542" type="direct"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-138422" status="INCOMING">
          <orgName>St Mary's Hospital Manchester</orgName>
          <desc>
            <address>
              <country key="GB"/>
            </address>
          </desc>
          <listRelation>
            <relation active="#struct-333835" type="direct"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-138423" status="INCOMING">
          <orgName>Wythenshawe Hospital</orgName>
          <desc>
            <address>
              <country key="GB"/>
            </address>
          </desc>
          <listRelation>
            <relation active="#struct-333836" type="direct"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-138424" status="INCOMING">
          <orgName>Division of Medical Oncology, Princess Margaret Hospital, Toronto, M5G 2M9</orgName>
          <desc>
            <address>
              <country key="GB"/>
            </address>
          </desc>
          <listRelation>
            <relation active="#struct-333837" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-333833" status="INCOMING">
          <orgName>St Mary's Manchester</orgName>
          <desc>
            <address>
              <country key="GB"/>
            </address>
          </desc>
        </org>
        <org type="institution" xml:id="struct-333834" status="INCOMING">
          <orgName>St Marys Hospital, Manchester</orgName>
          <desc>
            <address>
              <country key="FR"/>
            </address>
          </desc>
        </org>
        <org type="institution" xml:id="struct-328542" status="INCOMING">
          <orgName>The Christie</orgName>
          <desc>
            <address>
              <country key="FR"/>
            </address>
          </desc>
        </org>
        <org type="institution" xml:id="struct-333835" status="INCOMING">
          <orgName>St Mary's Hospital Manchester</orgName>
          <desc>
            <address>
              <country key="FR"/>
            </address>
          </desc>
        </org>
        <org type="institution" xml:id="struct-333836" status="INCOMING">
          <orgName>Wythenshawe Hospital</orgName>
          <desc>
            <address>
              <country key="FR"/>
            </address>
          </desc>
        </org>
        <org type="institution" xml:id="struct-333837" status="INCOMING">
          <orgName>Division of Medical Oncology, Princess Margaret Hospital, Toronto, M5G 2M9</orgName>
          <desc>
            <address>
              <country key="FR"/>
            </address>
          </desc>
        </org>
      </listOrg>
    </back>
  </text>
</TEI>