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Article Dans Une Revue International Journal of Mass Spectrometry Année : 2011

Atmospheric pressure photoionization of peptides

Résumé

In this work, fragmentations of peptides under atmospheric pressure photoionization conditions are further investigated for a model peptide. In the positive ion mode, intensive fragmentations are observed, mainly ascribed to c-sequence ions along with less abundant a- and b- type ions. The same features and c- ion series are reported for the negative ion mode, thereby suggesting a common mechanistic origin for the fragmentation in both ion modes. Moreover, it is shown that ECD-like fragmentation under APPI conditions may retain non-covalent adducts. This interesting property positions APPI as a promising ECD-like technique for in-source top down sequencing. (C) 2010 Elsevier B.V. All rights reserved.

Dates et versions

hal-00551618 , version 1 (04-01-2011)

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Citer

A. Bagag, A. Giuliani, O. Laprévote. Atmospheric pressure photoionization of peptides. International Journal of Mass Spectrometry, 2011, 299 (1), pp.1-4. ⟨10.1016/j.ijms.2010.08.010⟩. ⟨hal-00551618⟩
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