The Handy Use of Brown's P2-Ni Catalyst for a Skipped Diyne Deuteration: Application to the Synthesis of a [D(4)]-Labeled F(4t)-Neuroprostane.
Résumé
Brown's P2-Ni does the job: An efficient synthesis of tetradeuterated neuroprostane (see structure) has been accomplished by using an eneˆdiyne stereoselective mots cles : 15-D2-IsoP; 15-E2t-IsoP; total synthesis; selective enzymatic chemical differentiation of a non-meso-1,5-diols
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