Predominance of hepatitis C virus genotype 4 infection and rapid transmission between 1935 and 1965 in the Central African Republic. - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Journal of General Virology Année : 2009

Predominance of hepatitis C virus genotype 4 infection and rapid transmission between 1935 and 1965 in the Central African Republic.

Eric Frost
Sylvie Deslandes
  • Fonction : Auteur
Fleurie Mamadou-Yaya
  • Fonction : Auteur
Annie-Claude Labbé
  • Fonction : Auteur
Pascal M'Belesso
  • Fonction : Auteur
  • PersonId : 905238
Sylvestre Mbadingai
  • Fonction : Auteur
Dominique Rousset
Jacques Pépin
  • Fonction : Auteur

Résumé

The molecular epidemiology of hepatitis C virus (HCV) in the Central African Republic (CAR) is poorly documented. Thus, we conducted phylogenetic analyses of NS5B gene sequences from 58 HCV-infected inhabitants of a remote area of south-west CAR, which indicated that 48 (82.8%) were infected with genotype 4 (HCV-4), five (8.6%) with genotype 2 and five (8.6%) with genotype 1. HCV-4 strains were highly heterogeneous, containing previously described subtypes 4k (48%), 4c (27%), 4r (4%), 4f (4%) and unclassified subtypes (17%). To estimate the epidemic history of these HCV-4 strains, an evolutionary analysis using the coalescent approach was used. The estimated date of the most recent common ancestor of the CAR HCV-4 strains was 1539 (95% confidence intervals, 1317-1697). They exhibited a rapid, exponential spread from 1935 to 1965, simultaneously with what was recently reported in neighbouring Cameroon and Gabon. The hypothesis of a massive iatrogenic transmission during interventions for the control of endemic tropical diseases is discussed.

Domaines

Virologie

Dates et versions

hal-00542174 , version 1 (01-12-2010)

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Citer

Richard Njouom, Eric Frost, Sylvie Deslandes, Fleurie Mamadou-Yaya, Annie-Claude Labbé, et al.. Predominance of hepatitis C virus genotype 4 infection and rapid transmission between 1935 and 1965 in the Central African Republic.. Journal of General Virology, 2009, 90 (Pt 10), pp.2452-6. ⟨10.1099/vir.0.011981-0⟩. ⟨hal-00542174⟩

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