Reading microdots of a molecularly imprinted polymer by surface-enhanced Raman spectroscopy. - Archive ouverte HAL Access content directly
Journal Articles Biosensors and Bioelectronics Year : 2010

Reading microdots of a molecularly imprinted polymer by surface-enhanced Raman spectroscopy.

K. Kantarovich
  • Function : Author
I. Tsarfati
  • Function : Author
L.A. Gheber
  • Function : Author
Karsten Haupt
  • Function : Author
  • PersonId : 834899
I. Bar
  • Function : Author

Abstract

Writing a molecularly imprinted polymer (MIP) by nano-fountain pen on surface-enhanced Raman scattering (SERS)-active surfaces resulted in site-controlled arrays of microdots of approximately 6–12 μm in diameter. The monitoring of SERS spectra with a micro-Raman system enabled examining the uptake and release of the S-propranolol imprinting template and allowed imaging individual dots as well as multiple dots in an array, revealing the distribution of the imprinted polymer. This distribution was confirmed by atomic force microscopy, showing that even in dots of <300 nm thickness, corresponding to MIP volumes of 0.5 fl, significantly less than previously reported, the target analyte could be detected and identified. This study shows that nanolithography techniques combined with SERS might open the possibility of miniaturized arrayed MIP sensors with label-free, specific and quantitative detection.
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Dates and versions

hal-00535994 , version 1 (14-11-2010)

Identifiers

  • HAL Id : hal-00535994 , version 1

Cite

K. Kantarovich, I. Tsarfati, L.A. Gheber, Karsten Haupt, I. Bar. Reading microdots of a molecularly imprinted polymer by surface-enhanced Raman spectroscopy.. Biosensors and Bioelectronics, 2010, 26, pp.809-814. ⟨hal-00535994⟩
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