Reversible loss of N-acetyl-aspartate in rats subjected to long-term focal cerebral ischemia. - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Journal of Cerebral Blood Flow and Metabolism Année : 2003

Reversible loss of N-acetyl-aspartate in rats subjected to long-term focal cerebral ischemia.

Nathalie Bertrand
  • Fonction : Auteur
Anne Prigent-Tessier
  • Fonction : Auteur
Claude Mossiat
  • Fonction : Auteur
Maurice Giroud
  • Fonction : Auteur
Christine Marie
  • Fonction : Auteur
Alain Beley
  • Fonction : Auteur

Résumé

To evaluate the true meaning of N-acetyl-aspartate (NAA) measurements in ischemic stroke, the authors followed the temporal changes in brain NAA content in rats subjected to permanent focal ischemia. Ischemia was induced by photothrombotic cortical occlusion. At 1, 3, 8, and 30 d after onset of ischemia, NAA was measured in the infarct by high-performance liquid chromatography coupled to ultraviolet detection and histologic damage was examined. Cerebral content of NAA was markedly reduced in the lesioned tissue, reaching -90% after 3 d, a time at which viable neurons were no longer detected. N-Acetyl-aspartate concentrations after 8 and 30 d were higher than that observed after 3 d. This metabolic change coincided with an important microglial and astroglial activation. The results of this study raise questions regarding the use of NAA as a specific neuronal marker in chronic stage of stroke.
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Dates et versions

hal-00502159 , version 1 (13-07-2010)

Identifiants

  • HAL Id : hal-00502159 , version 1
  • PUBMED : 12679725

Citer

Céline Demougeot, Nathalie Bertrand, Anne Prigent-Tessier, Philippe Garnier, Claude Mossiat, et al.. Reversible loss of N-acetyl-aspartate in rats subjected to long-term focal cerebral ischemia.. Journal of Cerebral Blood Flow and Metabolism, 2003, 23 (4), pp.482-489. ⟨hal-00502159⟩
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