Fatigue crack growth tests in mixed-mode II + III were performed on maraging steel and Ti-6Al- 4V. The 3D evolutions of the crack fronts -measured by SEM after interrupted tests- were analyzed, taking into account the reduction in effective crack driving force by the interlocking and friction of the asperities of the crack surface. Under small-scale yielding conditions, the mixed-mode crack growth rates were found to correlate best with Keff2 II + 1.2Keff2 III in maraging steel, while for Ti-6Al-4V, Keff2 II + 0.9Keff2 III appeared suitable. For extended plasticity, a crack growth prediction method is proposed and validated for Ti-6Al-4V. This method is based on elastic-plastic F.E. computations and application, ahead of each node of the crack front, of a shear-dominated fatigue criterion.