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Article Dans Une Revue Clinical Nutrition Année : 2008

Inulin supplementation prevents high fructose diet-induced hypertension in rats.

Marie-Hélène Rault-Nania
  • Fonction : Auteur
Elyett Gueux
  • Fonction : Auteur
Stanislaw Dzimira
  • Fonction : Auteur
Yves Rayssiguier
  • Fonction : Auteur
Edmond Rock
  • Fonction : Auteur
André Mazur

Résumé

BACKGROUND & AIMS: The aim of this experiment was to evaluate the potential beneficial effect of supplementation with different inulin-type fructan fractions against common features of the metabolic syndrome in a rat model of this syndrome (fructose-fed rat). METHODS: Forty Wistar rats were randomly divided into five groups and the animals received for 4 weeks either a semi-purified starch or fructose-based diet, or diets in which fructose was partially substituted with various fructans: 10 g/100 g of long-chain inulin or oligofructose, or an oligofructose-enriched inulin. After this period, blood pressure was measured and samples of blood and tissues were collected for selected biochemical analyses. RESULTS: As compared to the starch-fed group, the fructose-fed rats presented: hypertriglyceridemia, hypertension, increased susceptibility to heart peroxidation and renal damages. Long-chain inulin and oligofructose-enriched inulin supplementation prevented fructose induced elevated blood pressure, susceptibility to heart peroxidation and renal damages. All inulin-type fructans containing diets prevented fructose induced hypertriglyceridemia. CONCLUSIONS: These results suggest that supplementation with inulin-type fructans is efficient against fructose induced hypertension and that effects are most pronounced for long-chain inulin and oligofructose-enriched inulin. We hypothesize that the anti-hypertensive effect of inulin could be explained by the reduction of the high fructose induced oxidative stress.

Dates et versions

hal-00493832 , version 1 (21-06-2010)

Identifiants

Citer

Marie-Hélène Rault-Nania, Céline Demougeot, Elyett Gueux, Alain Berthelot, Stanislaw Dzimira, et al.. Inulin supplementation prevents high fructose diet-induced hypertension in rats.. Clinical Nutrition, 2008, 27 (2), pp.276-282. ⟨10.1016/j.clnu.2008.01.015⟩. ⟨hal-00493832⟩

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