Microwave-Assisted Neat Procedure for the Petasis Reaction - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Synthesis: Journal of Synthetic Organic Chemistry Année : 2010

Microwave-Assisted Neat Procedure for the Petasis Reaction

Résumé

A new solvent-free microwave-assisted procedure for the Petasis multicomponent reaction was developed. This method is the first application of the borono-Mannich reaction in solvent-free conditions and proved its applicability to various boronic acids and secondary amines. Results are very good in term of yields, with shorter reaction time than with classic methods. Because of the efficiency of the method, full conversion of the starting materials towards the expected product was achieved, starting from stoichiometric quantities of reactants, avoiding the usual solvent consuming column chromatography on silica gel. No other purification step than an aqueous washing was required.
Fichier non déposé

Dates et versions

hal-00491946 , version 1 (14-06-2010)

Identifiants

Citer

Pierrick Nun, Jean Martinez, Frédéric Lamaty. Microwave-Assisted Neat Procedure for the Petasis Reaction. Synthesis: Journal of Synthetic Organic Chemistry, 2010, 12, pp.2063-2068. ⟨10.1055/s-0029-1218727⟩. ⟨hal-00491946⟩
96 Consultations
0 Téléchargements

Altmetric

Partager

Gmail Mastodon Facebook X LinkedIn More