Control of T cell reactivation by regulatory Qa-1 restricted CD8+ T cells. - Archive ouverte HAL
Article Dans Une Revue Journal of Immunology Année : 2010

Control of T cell reactivation by regulatory Qa-1 restricted CD8+ T cells.

A. Varthaman
  • Fonction : Auteur
M. Clement
  • Fonction : Auteur
G. Fornassa
  • Fonction : Auteur
Hj Kim
  • Fonction : Auteur
A.T. Gaston
  • Fonction : Auteur
G. Galigiuri
  • Fonction : Auteur
S. Kaveri
H. Cantor
  • Fonction : Auteur
A. Nicoletti
  • Fonction : Auteur

Résumé

Administration of attenuated pathogenic T cell clones, a procedure known as T cell vaccination, induces CD8(+) T cells specific for peptides derived from the V beta-chain of the TCR presented by the MHC class Ib molecule, Qa-1 expressed on the vaccine cells. These regulatory CD8(+) T cells have the capacity to control the activation of endogenous T cells expressing the same TCR V beta-chain as the vaccinating cells. We hypothesized that vaccination with NKT cells could also induce Qa-1-restricted CD8(+) T cells that would control NKT cell activation. We tested this hypothesis in a murine model of Con A-induced hepatitis that is induced by NKT cells. Vaccination with NKT cells effectively induced protective Qa-1-restricted CD8(+) T cells that prevented hepatitis. Surprisingly, upon vaccination with T cells expressing V beta-chains irrelevant to NKT cells, we discovered that the specificity of vaccine-induced Qa-1-restricted CD8(+) T cells was not limited to the V beta-chain of the vaccinating cells. We further show that these regulatory Qa-1-restricted CD8(+) T cells arise spontaneously upon polyclonal activation of T cells in the absence of deliberate T cell vaccination. These experiments provide new insight into a CD8(+) T cell compartment that regulates the immediate reactivation of conventional T cells and NKT cells.

Domaines

Immunologie

Dates et versions

hal-00486871 , version 1 (27-05-2010)

Identifiants

Citer

A. Varthaman, J. Khallou-Laschet, M. Clement, G. Fornassa, Hj Kim, et al.. Control of T cell reactivation by regulatory Qa-1 restricted CD8+ T cells.. Journal of Immunology, 2010, 184 (12), pp.6585-6591. ⟨10.4049/jimmunol.0903109⟩. ⟨hal-00486871⟩
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