A single-family house and its ventilation systems are simulated using SIMBAD Toolbox, a combined mass and heat transfer model implemented in MATLAB/Simulink environment. Numerical investigations are then performed with four ventilation systems for a heating period. This paper deals with the simulation results with regard to indoor air quality and energy demand. These results show that the best performances are obtained by using mechanical balanced ventilation: the total energy savings that can be expected, compared to the reference system, is about 22 to 31% depending on the efficiency of the heat exchanger. Balanced ventilation also appears to be an accurate strategy for assuring better IAQ, while the humidity-controlled ventilation systems, although allowing a great reduction in energy demand (18 to 22%), fail at times to ensure a good IAQ. Besides, natural ventilation system, though seems to be oversized, yields a worse IAQ performance and obviously a great energy losses (+18.5%).