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            <title xml:lang="en">Phosphatidylcholine/sphingomyelin metabolism crosstalk inside the nucleus</title>
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                <forename type="first">Elisabetta</forename>
                <surname>Albi</surname>
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                <title xml:lang="en">Phosphatidylcholine/sphingomyelin metabolism crosstalk inside the nucleus</title>
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                    <forename type="first">Elisabetta</forename>
                    <surname>Albi</surname>
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                    <surname>Viola Magni</surname>
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              <p>It is known that the phospholipids represent a "minor component" of chromatin. Recently it has been highlighted that these lipids are metabolised directly inside the nucleus thanks to the presence of the enzymes related to their metabolism such as neutral sphingomyelinase, sphingomyelin-synthase, reverse sphingomyelin-synthase and phosphatidylcholine-specific phospholipase C. The chromatin enzymatic activities change during cell proliferation, differentiation and/or apoptosis independently of the enzyme activities present in the nuclear membrane, microsomes or cell membranes. The present research was aimed to investigate the crosstalk of the lipid metabolisms in nuclear membrane and chromatin isolated from rat liver in vitro and in vivo. The effect of neutral-sphingomyelinase activity on phosphatidylcholine-specific phospholipase C and sphingomyelin-synthase, which enrich the intranuclear diacylglycerol pool and the effect of phosphatidylcholine-specific phospholipase C activity on neutral sphingomyelinase and reverse sphingomyelin-synthase, which enrich the intranuclear ceramide pool, were investigated. The results show that in chromatin exists a phosphatidylcholine/sphingomyelin metabolism crosstalk which regulates the intranuclear ceramide/diacylglycerol pool. Its specificity was demonstrated by D609 inhibitor effect. The chromatin lipid metabolism is activated in vivo during cell proliferation indicating that it could play a role on cell function. The possible mechanism of the crosstalk was discussed considering the recent literature in the field.</p>
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