<?xml version="1.0" encoding="utf-8"?>
<TEI xmlns="http://www.tei-c.org/ns/1.0" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:hal="http://hal.archives-ouvertes.fr/" xmlns:gml="http://www.opengis.net/gml/3.3/" xmlns:gmlce="http://www.opengis.net/gml/3.3/ce" version="1.1" xsi:schemaLocation="http://www.tei-c.org/ns/1.0 http://api.archives-ouvertes.fr/documents/aofr-sword.xsd">
  <teiHeader>
    <fileDesc>
      <titleStmt>
        <title>HAL TEI export of hal-00478254</title>
      </titleStmt>
      <publicationStmt>
        <distributor>CCSD</distributor>
        <availability status="restricted">
          <licence target="https://creativecommons.org/publicdomain/zero/1.0/">CC0 1.0 - Universal</licence>
        </availability>
        <date when="2026-05-22T07:58:51+02:00"/>
      </publicationStmt>
      <sourceDesc>
        <p part="N">HAL API Platform</p>
      </sourceDesc>
    </fileDesc>
  </teiHeader>
  <text>
    <body>
      <listBibl>
        <biblFull>
          <titleStmt>
            <title xml:lang="en">Venlafaxine versus clonidine for the treatment of hot flashes in breast cancer patients: a double-blind, randomized cross-over study</title>
            <author role="aut">
              <persName>
                <forename type="first">Ciska</forename>
                <surname>Buijs</surname>
              </persName>
              <idno type="halauthorid">456228-0</idno>
              <affiliation ref="#struct-131861"/>
            </author>
            <author role="crp">
              <persName>
                <forename type="first">Constantijne H.</forename>
                <surname>Mom</surname>
              </persName>
              <email type="md5">16b431a8760d2eea0dc51da9a53aab66</email>
              <email type="domain">og.umcg.nl</email>
              <idno type="idhal" notation="numeric">869737</idno>
              <idno type="halauthorid" notation="string">456229-869737</idno>
              <affiliation ref="#struct-131861"/>
              <affiliation ref="#struct-131861"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Pax H. B.</forename>
                <surname>Willemse</surname>
              </persName>
              <idno type="halauthorid">456230-0</idno>
              <affiliation ref="#struct-131861"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">H.</forename>
                <surname>Marike Boezen</surname>
              </persName>
              <idno type="halauthorid">456231-0</idno>
              <affiliation ref="#struct-113403"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">J. Marina</forename>
                <surname>Maurer</surname>
              </persName>
              <idno type="halauthorid">456232-0</idno>
              <affiliation ref="#struct-162742"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">A. N. Machteld</forename>
                <surname>Wymenga</surname>
              </persName>
              <idno type="halauthorid">456233-0</idno>
              <affiliation ref="#struct-131861"/>
              <affiliation ref="#struct-113405"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Robert S.</forename>
                <surname>Jong</surname>
              </persName>
              <idno type="halauthorid">456234-0</idno>
              <affiliation ref="#struct-131861"/>
              <affiliation ref="#struct-113406"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Peter</forename>
                <surname>Nieboer</surname>
              </persName>
              <idno type="halauthorid">456235-0</idno>
              <affiliation ref="#struct-131861"/>
              <affiliation ref="#struct-113407"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Elisabeth G. E.</forename>
                <surname>Vries</surname>
              </persName>
              <idno type="halauthorid">455666-0</idno>
              <affiliation ref="#struct-131861"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Marian J. E.</forename>
                <surname>Mourits</surname>
              </persName>
              <idno type="halauthorid">456236-0</idno>
              <affiliation ref="#struct-131861"/>
            </author>
            <editor role="depositor">
              <persName>
                <forename>Hal</forename>
                <surname>Peer</surname>
              </persName>
              <email type="md5">8d58fc1b670b8074dd83e4a4c93d5914</email>
              <email type="domain">inria.fr</email>
            </editor>
          </titleStmt>
          <editionStmt>
            <edition n="v1" type="current">
              <date type="whenSubmitted">2010-04-30 14:27:48</date>
              <date type="whenWritten">2008-07-12</date>
              <date type="whenModified">2026-03-26 11:22:03</date>
              <date type="whenReleased">2010-04-30 14:27:48</date>
              <date type="whenProduced">2008-08-01</date>
              <date type="whenEndEmbargoed">2010-04-30</date>
              <ref type="file" target="https://hal.science/hal-00478254v1/document">
                <date notBefore="2010-04-30"/>
              </ref>
              <ref type="file" subtype="author" n="1" target="https://hal.science/hal-00478254v1/file/PEER_stage2_10.1007%252Fs10549-008-0138-7.pdf" id="file-478254-587445">
                <date notBefore="2010-04-30"/>
              </ref>
              <ref type="externalLink" target="https://api.istex.fr/document/441071F8BDBBF0A5C332219C1E7799F645A2D20A/fulltext/pdf?sid=hal"/>
            </edition>
            <respStmt>
              <resp>contributor</resp>
              <name key="148147">
                <persName>
                  <forename>Hal</forename>
                  <surname>Peer</surname>
                </persName>
                <email type="md5">8d58fc1b670b8074dd83e4a4c93d5914</email>
                <email type="domain">inria.fr</email>
              </name>
            </respStmt>
          </editionStmt>
          <publicationStmt>
            <distributor>CCSD</distributor>
            <idno type="halId">hal-00478254</idno>
            <idno type="halUri">https://hal.science/hal-00478254</idno>
            <idno type="halBibtex">buijs:hal-00478254</idno>
            <idno type="halRefHtml">&lt;i&gt;Breast Cancer Research and Treatment&lt;/i&gt;, 2008, 115 (3), pp.573-580. &lt;a target="_blank" href="https://dx.doi.org/10.1007/s10549-008-0138-7"&gt;&amp;#x27E8;10.1007/s10549-008-0138-7&amp;#x27E9;&lt;/a&gt;</idno>
            <idno type="halRef">Breast Cancer Research and Treatment, 2008, 115 (3), pp.573-580. &amp;#x27E8;10.1007/s10549-008-0138-7&amp;#x27E9;</idno>
            <availability status="restricted">
              <licence target="https://about.hal.science/hal-authorisation-v1/">HAL Authorization<ref corresp="#file-478254-587445"/></licence>
            </availability>
          </publicationStmt>
          <seriesStmt>
            <idno type="stamp" n="PEER">PEER Publishing and the Ecology of European Research</idno>
          </seriesStmt>
          <notesStmt>
            <note type="audience" n="2">International</note>
            <note type="popular" n="0">No</note>
            <note type="peer" n="1">Yes</note>
          </notesStmt>
          <sourceDesc>
            <biblStruct>
              <analytic>
                <title xml:lang="en">Venlafaxine versus clonidine for the treatment of hot flashes in breast cancer patients: a double-blind, randomized cross-over study</title>
                <author role="aut">
                  <persName>
                    <forename type="first">Ciska</forename>
                    <surname>Buijs</surname>
                  </persName>
                  <idno type="halauthorid">456228-0</idno>
                  <affiliation ref="#struct-131861"/>
                </author>
                <author role="crp">
                  <persName>
                    <forename type="first">Constantijne H.</forename>
                    <surname>Mom</surname>
                  </persName>
                  <email type="md5">16b431a8760d2eea0dc51da9a53aab66</email>
                  <email type="domain">og.umcg.nl</email>
                  <idno type="idhal" notation="numeric">869737</idno>
                  <idno type="halauthorid" notation="string">456229-869737</idno>
                  <affiliation ref="#struct-131861"/>
                  <affiliation ref="#struct-131861"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Pax H. B.</forename>
                    <surname>Willemse</surname>
                  </persName>
                  <idno type="halauthorid">456230-0</idno>
                  <affiliation ref="#struct-131861"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">H.</forename>
                    <surname>Marike Boezen</surname>
                  </persName>
                  <idno type="halauthorid">456231-0</idno>
                  <affiliation ref="#struct-113403"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">J. Marina</forename>
                    <surname>Maurer</surname>
                  </persName>
                  <idno type="halauthorid">456232-0</idno>
                  <affiliation ref="#struct-162742"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">A. N. Machteld</forename>
                    <surname>Wymenga</surname>
                  </persName>
                  <idno type="halauthorid">456233-0</idno>
                  <affiliation ref="#struct-131861"/>
                  <affiliation ref="#struct-113405"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Robert S.</forename>
                    <surname>Jong</surname>
                  </persName>
                  <idno type="halauthorid">456234-0</idno>
                  <affiliation ref="#struct-131861"/>
                  <affiliation ref="#struct-113406"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Peter</forename>
                    <surname>Nieboer</surname>
                  </persName>
                  <idno type="halauthorid">456235-0</idno>
                  <affiliation ref="#struct-131861"/>
                  <affiliation ref="#struct-113407"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Elisabeth G. E.</forename>
                    <surname>Vries</surname>
                  </persName>
                  <idno type="halauthorid">455666-0</idno>
                  <affiliation ref="#struct-131861"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Marian J. E.</forename>
                    <surname>Mourits</surname>
                  </persName>
                  <idno type="halauthorid">456236-0</idno>
                  <affiliation ref="#struct-131861"/>
                </author>
              </analytic>
              <monogr>
                <idno type="halJournalId" status="VALID">11294</idno>
                <idno type="issn">0167-6806</idno>
                <idno type="eissn">1573-7217</idno>
                <title level="j">Breast Cancer Research and Treatment</title>
                <imprint>
                  <publisher>Springer Verlag</publisher>
                  <biblScope unit="volume">115</biblScope>
                  <biblScope unit="issue">3</biblScope>
                  <biblScope unit="pp">573-580</biblScope>
                  <date type="datePub">2008-08-01</date>
                </imprint>
              </monogr>
              <idno type="doi">10.1007/s10549-008-0138-7</idno>
            </biblStruct>
          </sourceDesc>
          <profileDesc>
            <langUsage>
              <language ident="en">English</language>
            </langUsage>
            <textClass>
              <keywords scheme="author">
                <term xml:lang="en">Breast cancer</term>
                <term xml:lang="en">Hot flashes</term>
                <term xml:lang="en">Menopause</term>
                <term xml:lang="en">Clonidine</term>
                <term xml:lang="en">Venlafaxine</term>
              </keywords>
              <classCode scheme="halTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halOldTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halTreeTypology" n="ART">Journal articles</classCode>
            </textClass>
            <abstract xml:lang="en">
              <p>Breast cancer patients with treatment-induced menopause experience frequent and severe hot flashes (HF). We compared venlafaxine and clonidine for the treatment of HF with regard to side effects, efficacy, quality of life and sexual functioning. In a double-blind, cross-over study, 60 breast cancer patients experiencing HF were randomized to 8 weeks venlafaxine followed by 2 weeks wash-out, and 8 weeks clonidine or vice versa. HF frequency and severity, side effects, quality of life and sexuality were assessed. Thirty patients started with venlafaxine and 30 with clonidine. Premature discontinuation for toxicity occurred in 14/59 during venlafaxine and 5/53 during clonidine ( = .038). Venlafaxine induced more side effects. Median reduction in HF score was 49% for venlafaxine and 55% for clonidine (ns). Venlafaxine and clonidine are equally, but moderately effective in HF reduction. Side effects are the main reason for drug discontinuation, occurring more often with venlafaxine.</p>
            </abstract>
          </profileDesc>
        </biblFull>
      </listBibl>
    </body>
    <back>
      <listOrg type="structures">
        <org type="institution" xml:id="struct-131861" status="VALID">
          <idno type="ISNI">0000 0004 0407 1981</idno>
          <idno type="ROR">https://ror.org/012p63287</idno>
          <idno type="Wikidata">Q850730</idno>
          <orgName>University of Groningen [Groningen]</orgName>
          <date type="start">1614-01-01</date>
          <desc>
            <address>
              <addrLine>PO Box 72 , 9700 AB Groningen</addrLine>
              <country key="NL"/>
            </address>
            <ref type="url">http://www.rug.nl/</ref>
          </desc>
        </org>
        <org type="laboratory" xml:id="struct-113403" status="INCOMING">
          <orgName>Department of Epidemiology</orgName>
          <desc>
            <address>
              <addrLine>Groningen</addrLine>
              <country key="NL"/>
            </address>
          </desc>
          <listRelation>
            <relation active="#struct-162742" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-162742" status="VALID">
          <idno type="ROR">https://ror.org/03cv38k47</idno>
          <orgName>University Medical Center Groningen [Groningen]</orgName>
          <orgName type="acronym">UMCG</orgName>
          <desc>
            <address>
              <addrLine>PO box 30.0019700 RB Groningen</addrLine>
              <country key="NL"/>
            </address>
            <ref type="url">https://www.umcg.nl/EN/</ref>
          </desc>
        </org>
        <org type="laboratory" xml:id="struct-113405" status="INCOMING">
          <orgName>Medical Spectrum Twente</orgName>
          <desc>
            <address>
              <addrLine>Enschede</addrLine>
              <country key="NL"/>
            </address>
          </desc>
          <listRelation>
            <relation active="#struct-327331" type="direct"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-113406" status="INCOMING">
          <orgName>Martini Hospital</orgName>
          <desc>
            <address>
              <addrLine>Groningen</addrLine>
              <country key="NL"/>
            </address>
          </desc>
          <listRelation>
            <relation active="#struct-327332" type="direct"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-113407" status="INCOMING">
          <orgName>Wilhelmina Hospital</orgName>
          <desc>
            <address>
              <addrLine>Assen</addrLine>
              <country key="NL"/>
            </address>
          </desc>
          <listRelation>
            <relation active="#struct-327333" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-327331" status="INCOMING">
          <orgName>Medical Spectrum Twente</orgName>
          <desc>
            <address>
              <country key="FR"/>
            </address>
          </desc>
        </org>
        <org type="institution" xml:id="struct-327332" status="INCOMING">
          <orgName>Martini Hospital</orgName>
          <desc>
            <address>
              <country key="FR"/>
            </address>
          </desc>
        </org>
        <org type="institution" xml:id="struct-327333" status="INCOMING">
          <orgName>Wilhelmina Hospital</orgName>
          <desc>
            <address>
              <country key="FR"/>
            </address>
          </desc>
        </org>
      </listOrg>
    </back>
  </text>
</TEI>