Ontology previously belonged to the field of philosophy. It is now applied in practical computer applications. Through NICT, globalisation encourages the emergence of networks that overcome traditional organisation boundaries. Knowledge is now a key resource that confuses traditional, organisational, economic and innovative models. International enterprises, European-Community Networks of Excellence or French Competitiveness Poles indicate the need to define a new way of thinking. This new way moves towards an agile, continuous innovative use of knowledge. Based on an epistemic study of knowledge management best practices, four examples show the barriers that can be encountered today. Best practices from collaborative platforms enable the design of high standard information systems and initiate knowledge ecosystems. A balance has to be obtained between the formalism required to apply knowledge and the fuzziness of social networks that triggers new initiatives. This ensures the validity of information exchange through virtual collaboration. It helps to maintain group coherence despite exceeding the natural maximum number of collaborators. The transition from economic-driven to expertise-driven models is then facilitated.