Divided medium-based model for analyzing the dynamic reorganization of the cytoskeleton during cell deformation - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Biomechanics and Modeling in Mechanobiology Année : 2007

Divided medium-based model for analyzing the dynamic reorganization of the cytoskeleton during cell deformation

Résumé

Cell deformability and mechanical responses of living cells depend closely on the dynamic changes in the structural architecture of the cytoskeleton (CSK). To describe the dynamic reorganization and the heterogeneity of the prestressed multi-modular CSK, we developed a two-dimensional model for the CSK which was taken to be a system of tension and compression interactions between the nodes in a divided medium. The model gives the dynamic reorganization of the CSK consisting of fast changes in connectivity between nodes during medium deformation and the resulting mechanical behavior is consistent with the strain-hardening and prestress-induced stiffening observed in cells in vitro. In addition, the interaction force networks which occur and balance to each other in the model can serve to identify the main CSK substructures: cortex, stress fibers, intermediate filaments, microfilaments, microtubules and focal adhesions. Removing any of these substructures results in a loss of integrity in the model and a decrease in the prestress and stiffness, and suggests that the CSK substructures are highly interdependent. The present model may therefore provide a useful tool for understanding the cellular processes involving CSK reorganization, such as mechanotransduction, migration and adhesion processes.
Fichier principal
Vignette du fichier
Milan2007_BMMB.pdf (1.1 Mo) Télécharger le fichier
Origine : Accord explicite pour ce dépôt
Loading...

Dates et versions

hal-00475545 , version 1 (15-11-2017)

Identifiants

Citer

Jean-Louis Milan, Sylvie Wendling-Mansuy, Michel Jean, Patrick Chabrand. Divided medium-based model for analyzing the dynamic reorganization of the cytoskeleton during cell deformation. Biomechanics and Modeling in Mechanobiology, 2007, 6 (6), pp.373-390. ⟨10.1007/s10237-006-0057-7⟩. ⟨hal-00475545⟩
74 Consultations
84 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More