<?xml version="1.0" encoding="utf-8"?>
<TEI xmlns="http://www.tei-c.org/ns/1.0" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:hal="http://hal.archives-ouvertes.fr/" xmlns:gml="http://www.opengis.net/gml/3.3/" xmlns:gmlce="http://www.opengis.net/gml/3.3/ce" version="1.1" xsi:schemaLocation="http://www.tei-c.org/ns/1.0 http://api.archives-ouvertes.fr/documents/aofr-sword.xsd">
  <teiHeader>
    <fileDesc>
      <titleStmt>
        <title>HAL TEI export of hal-00464973</title>
      </titleStmt>
      <publicationStmt>
        <distributor>CCSD</distributor>
        <availability status="restricted">
          <licence target="https://creativecommons.org/publicdomain/zero/1.0/">CC0 1.0 - Universal</licence>
        </availability>
        <date when="2026-05-22T09:03:11+02:00"/>
      </publicationStmt>
      <sourceDesc>
        <p part="N">HAL API Platform</p>
      </sourceDesc>
    </fileDesc>
  </teiHeader>
  <text>
    <body>
      <listBibl>
        <biblFull>
          <titleStmt>
            <title xml:lang="en">Antennal lobe processing increases separability of odor mixture representations in the honeybee.</title>
            <author role="aut">
              <persName>
                <forename type="first">N.</forename>
                <surname>Deisig</surname>
              </persName>
              <email type="md5">5aa11e60f36ce1fa22090103f8b6c3f9</email>
              <email type="domain">versailles.inra.fr</email>
              <idno type="idhal" notation="numeric">957147</idno>
              <idno type="halauthorid" notation="string">162751-957147</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-9052-0258</idno>
              <affiliation ref="#struct-650"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">M.</forename>
                <surname>Giurfa</surname>
              </persName>
              <email type="md5">6cb618c0a39b7a4bda366effe7107848</email>
              <email type="domain">univ-tlse3.fr</email>
              <idno type="idhal" notation="string">giurfa-martin</idno>
              <idno type="idhal" notation="numeric">5014</idno>
              <idno type="halauthorid" notation="string">162752-5014</idno>
              <idno type="ORCID">https://orcid.org/0000-0001-7173-769X</idno>
              <idno type="IDREF">https://www.idref.fr/098130129</idno>
              <affiliation ref="#struct-650"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">J.C.</forename>
                <surname>Sandoz</surname>
              </persName>
              <email type="md5">5fc83d81cc23acc2a853550bc7ec13c0</email>
              <email type="domain">egce.cnrs-gif.fr</email>
              <idno type="idhal" notation="string">jean-christophe-sandoz</idno>
              <idno type="idhal" notation="numeric">178800</idno>
              <idno type="halauthorid" notation="string">162757-178800</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-5423-9645</idno>
              <idno type="IDREF">https://www.idref.fr/079378595</idno>
              <affiliation ref="#struct-475"/>
            </author>
            <editor role="depositor">
              <persName>
                <forename>Christine</forename>
                <surname>Nicolas</surname>
              </persName>
              <email type="md5">c51191564538f3df4651034f54e1518e</email>
              <email type="domain">legs.cnrs-gif.fr</email>
            </editor>
          </titleStmt>
          <editionStmt>
            <edition n="v1" type="current">
              <date type="whenSubmitted">2010-03-18 15:21:57</date>
              <date type="whenModified">2025-10-22 18:04:08</date>
              <date type="whenReleased">2010-03-18 15:21:57</date>
              <date type="whenProduced">2010</date>
              <fs>
                <f name="inra_publicVise_local" notation="string" n="SC">
                  <string>inra_publicVise_local_SC</string>
                </f>
              </fs>
            </edition>
            <respStmt>
              <resp>contributor</resp>
              <name key="148721">
                <persName>
                  <forename>Christine</forename>
                  <surname>Nicolas</surname>
                </persName>
                <email type="md5">c51191564538f3df4651034f54e1518e</email>
                <email type="domain">legs.cnrs-gif.fr</email>
              </name>
            </respStmt>
          </editionStmt>
          <publicationStmt>
            <distributor>CCSD</distributor>
            <idno type="halId">hal-00464973</idno>
            <idno type="halUri">https://hal.science/hal-00464973</idno>
            <idno type="halBibtex">deisig:hal-00464973</idno>
            <idno type="halRefHtml">&lt;i&gt;Journal of Neurophysiology&lt;/i&gt;, 2010, 103, in press. &lt;a target="_blank" href="https://dx.doi.org/10.1152/jn.00342.2009"&gt;&amp;#x27E8;10.1152/jn.00342.2009&amp;#x27E9;&lt;/a&gt;</idno>
            <idno type="halRef">Journal of Neurophysiology, 2010, 103, in press. &amp;#x27E8;10.1152/jn.00342.2009&amp;#x27E9;</idno>
            <availability status="restricted"/>
          </publicationStmt>
          <seriesStmt>
            <idno type="stamp" n="UNIV-TLSE2">Université Toulouse 2</idno>
            <idno type="stamp" n="UNIV-TLSE3">Université de Toulouse</idno>
            <idno type="stamp" n="CNRS">CNRS - Centre national de la recherche scientifique</idno>
            <idno type="stamp" n="CRCA">Centre de recherches sur la cognition animale</idno>
            <idno type="stamp" n="EGCE">Evolution, Génomes, Comportement, Ecologie</idno>
            <idno type="stamp" n="UNIV-UT3">Université Toulouse 3</idno>
            <idno type="stamp" n="UT3-INP">Université de Toulouse / Toulouse INP</idno>
            <idno type="stamp" n="UT3-TOULOUSEINP">Université de Toulouse / Toulouse INP</idno>
            <idno type="stamp" n="CBI">Centre de biologie intégrative</idno>
          </seriesStmt>
          <notesStmt>
            <note type="audience" n="1">Not set</note>
            <note type="popular" n="0">No</note>
            <note type="peer" n="1">Yes</note>
          </notesStmt>
          <sourceDesc>
            <biblStruct>
              <analytic>
                <title xml:lang="en">Antennal lobe processing increases separability of odor mixture representations in the honeybee.</title>
                <author role="aut">
                  <persName>
                    <forename type="first">N.</forename>
                    <surname>Deisig</surname>
                  </persName>
                  <email type="md5">5aa11e60f36ce1fa22090103f8b6c3f9</email>
                  <email type="domain">versailles.inra.fr</email>
                  <idno type="idhal" notation="numeric">957147</idno>
                  <idno type="halauthorid" notation="string">162751-957147</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-9052-0258</idno>
                  <affiliation ref="#struct-650"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">M.</forename>
                    <surname>Giurfa</surname>
                  </persName>
                  <email type="md5">6cb618c0a39b7a4bda366effe7107848</email>
                  <email type="domain">univ-tlse3.fr</email>
                  <idno type="idhal" notation="string">giurfa-martin</idno>
                  <idno type="idhal" notation="numeric">5014</idno>
                  <idno type="halauthorid" notation="string">162752-5014</idno>
                  <idno type="ORCID">https://orcid.org/0000-0001-7173-769X</idno>
                  <idno type="IDREF">https://www.idref.fr/098130129</idno>
                  <affiliation ref="#struct-650"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">J.C.</forename>
                    <surname>Sandoz</surname>
                  </persName>
                  <email type="md5">5fc83d81cc23acc2a853550bc7ec13c0</email>
                  <email type="domain">egce.cnrs-gif.fr</email>
                  <idno type="idhal" notation="string">jean-christophe-sandoz</idno>
                  <idno type="idhal" notation="numeric">178800</idno>
                  <idno type="halauthorid" notation="string">162757-178800</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-5423-9645</idno>
                  <idno type="IDREF">https://www.idref.fr/079378595</idno>
                  <affiliation ref="#struct-475"/>
                </author>
              </analytic>
              <monogr>
                <idno type="halJournalId" status="VALID">15874</idno>
                <idno type="issn">0022-3077</idno>
                <idno type="eissn">1522-1598</idno>
                <title level="j">Journal of Neurophysiology</title>
                <imprint>
                  <publisher>American Physiological Society</publisher>
                  <biblScope unit="volume">103</biblScope>
                  <biblScope unit="pp">in press</biblScope>
                  <date type="datePub">2010</date>
                </imprint>
              </monogr>
              <idno type="doi">10.1152/jn.00342.2009</idno>
              <idno type="prodinra">33632</idno>
              <idno type="wos">000276555800044</idno>
              <ref target="http://gateway.isiknowledge.com/gateway/Gateway.cgi?&amp;GWVersion=2&amp;SrcAuth=INRA&amp;SrcApp=INRA&amp;DestLinkType=FullRecord&amp;DestApp=WOS&amp;KeyUT=000276555800044" type="seeAlso"/>
            </biblStruct>
          </sourceDesc>
          <profileDesc>
            <langUsage>
              <language ident="en">English</language>
            </langUsage>
            <textClass>
              <keywords scheme="author">
                <term xml:lang="en">OLFACTORY RECEPTOR NEURONS</term>
                <term xml:lang="en">FLY BRAIN</term>
                <term xml:lang="en">APIS-MELLIFERA L</term>
                <term xml:lang="en">SENSORY MAP</term>
                <term xml:lang="en">COMPONENTS</term>
                <term xml:lang="en">DROSOPHILA</term>
                <term xml:lang="fr">INSECTE</term>
                <term xml:lang="fr">SYSTEM</term>
                <term xml:lang="fr">RESPONSES</term>
                <term xml:lang="fr">CONFOCAL MICROSCOPY</term>
              </keywords>
              <classCode scheme="halDomain" n="sdv.ba">Life Sciences [q-bio]/Animal biology</classCode>
              <classCode scheme="vocinrae-old" n="lobe antennaire">lobe antennaire</classCode>
              <classCode scheme="vocinrae-old" n="neurone">neurone</classCode>
              <classCode scheme="vocinrae-old" n="odeur">odeur</classCode>
              <classCode scheme="vocinrae-old" n="apidae">apidae</classCode>
              <classCode scheme="vocinrae-old" n="microscopie">microscopie</classCode>
              <classCode scheme="vocinrae-old" n="diptera">diptera</classCode>
              <classCode scheme="vocinrae-old" n="olfaction">olfaction</classCode>
              <classCode scheme="vocinrae-old" n="propriété sensorielle">propriété sensorielle</classCode>
              <classCode scheme="vocinrae-old" n="récepteur">récepteur</classCode>
              <classCode scheme="vocinrae-old" n="hymenoptera">hymenoptera</classCode>
              <classCode scheme="halTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halOldTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halTreeTypology" n="ART">Journal articles</classCode>
            </textClass>
            <abstract xml:lang="en">
              <p>Local networks within the primary olfactory centers reformat odor representations from olfactory receptor neurons to second-order neurons. By studying the rules underlying mixture representation at the input to the antennal lobe (AL), the primary olfactory center of the insect brain, we recently found that mixture representation follows a strict elemental rule in honeybees: the more a component activates the AL when presented alone, the more it is represented in a mixture. We now studied mixture representation at the output of the AL by imaging a population of second-order neurons, which convey AL processed odor information to higher brain centers. We systematically measured odor-evoked activity in 22 identified glomeruli in response to four single odorants and all their possible binary, ternary and quaternary mixtures. By comparing input and output responses, we determined how the AL network reformats mixture representation and what advantage this confers for odor discrimination. We show that increased inhibition within the AL leads to more synthetic, less elemental, mixture representation at the output level than that at the input level. As a result, mixture representations become more separable in the olfactory space, thus allowing better differentiation among floral blends in nature.</p>
            </abstract>
          </profileDesc>
        </biblFull>
      </listBibl>
    </body>
    <back>
      <listOrg type="structures">
        <org type="laboratory" xml:id="struct-650" status="OLD">
          <idno type="IdRef">23842958X</idno>
          <idno type="ISNI">0000 0004 0383 0990</idno>
          <idno type="RNSR">200311842N</idno>
          <idno type="ROR">https://ror.org/0111s2360</idno>
          <orgName>Centre de Recherches sur la Cognition Animale - UMR5169</orgName>
          <orgName type="acronym">CRCA</orgName>
          <date type="start">2003-01-01</date>
          <date type="end">2020-12-31</date>
          <desc>
            <address>
              <addrLine>Centre de Recherches sur la Cognition Animale - UMR 5169CNRS, Université Paul Sabatier, Bât IVR3118, route de NarbonneF - 31062 Toulouse cedex 09</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://crca.cbi-toulouse.fr/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-1782" type="direct"/>
            <relation active="#struct-116256" type="indirect"/>
            <relation active="#struct-443875" type="indirect"/>
            <relation active="#struct-217752" type="indirect"/>
            <relation active="#struct-300075" type="indirect"/>
            <relation name="IFR96" active="#struct-303623" type="indirect"/>
            <relation name="IFR96" active="#struct-441569" type="indirect"/>
            <relation active="#struct-552481" type="direct"/>
            <relation name="FR3743" active="#struct-441569" type="indirect"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-475" status="OLD">
          <idno type="IdRef">157354709</idno>
          <idno type="ISNI">0000000406147687</idno>
          <idno type="RNSR">199817487W</idno>
          <idno type="ROR">https://ror.org/011abem59</idno>
          <orgName>Laboratoire Evolution, Génomes et Spéciation</orgName>
          <orgName type="acronym">LEGS</orgName>
          <desc>
            <address>
              <addrLine>avenue de la Terrasse Bâtiment 13, Boite Postale 1 91198 Gif sur Yvette</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.legs.cnrs-gif.fr/</ref>
          </desc>
          <listRelation>
            <relation name="UPR9034" active="#struct-441569" type="direct"/>
          </listRelation>
        </org>
        <org type="regrouplaboratory" xml:id="struct-1782" status="OLD">
          <orgName>Institut des sciences du cerveau de Toulouse.</orgName>
          <orgName type="acronym">ISCT</orgName>
          <date type="start">2000-01-01</date>
          <date type="end">2020-12-31</date>
          <desc>
            <address>
              <addrLine>CHU Purpan - Pavillon BaudotPlace du Dr. Baylac31059 Toulouse</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.ifr96.ups-tlse.fr/fr/isct.html</ref>
          </desc>
          <listRelation>
            <relation active="#struct-116256" type="direct"/>
            <relation active="#struct-443875" type="indirect"/>
            <relation active="#struct-217752" type="direct"/>
            <relation active="#struct-300075" type="direct"/>
            <relation name="IFR96" active="#struct-303623" type="direct"/>
            <relation name="IFR96" active="#struct-441569" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-116256" status="VALID">
          <idno type="IdRef">026403994</idno>
          <idno type="ROR">https://ror.org/04ezk3x31</idno>
          <orgName>Université Toulouse - Jean Jaurès</orgName>
          <orgName type="acronym">UT2J</orgName>
          <date type="start">1971-01-01</date>
          <desc>
            <address>
              <addrLine>5 allées Antonio Machado - 31058 Toulouse Cedex 9</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.univ-tlse2.fr</ref>
          </desc>
          <listRelation>
            <relation active="#struct-443875" type="direct"/>
          </listRelation>
        </org>
        <org type="regroupinstitution" xml:id="struct-443875" status="VALID">
          <idno type="ROR">https://ror.org/017tgbk05</idno>
          <orgName>Communauté d'universités et établissements de Toulouse</orgName>
          <orgName type="acronym">Comue de Toulouse</orgName>
          <desc>
            <address>
              <addrLine>41 Allée Jules Guesde, 31000 Toulouse</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.univ-toulouse.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-217752" status="OLD">
          <idno type="IdRef">026404672</idno>
          <idno type="ISNI">0000000121617331</idno>
          <idno type="ROR">https://ror.org/02v6kpv12</idno>
          <idno type="Wikidata">Q1273188</idno>
          <orgName>Université Toulouse III - Paul Sabatier</orgName>
          <orgName type="acronym">UT3</orgName>
          <date type="end">2025-01-01</date>
          <desc>
            <address>
              <addrLine>118 route de Narbonne - 31062 Toulouse</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.univ-tlse3.fr/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-443875" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-300075" status="VALID">
          <orgName>Centre Hospitalier Universitaire de Toulouse</orgName>
          <orgName type="acronym">CHU Toulouse</orgName>
          <desc>
            <address>
              <addrLine>regroupe les hôpitaux  Purpan, Rangueil, Pierre-Paul Riquet, Larey, Paule de Viguier, Hôtel Dieu Saint-Jacques, La Grave, etc.</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.chu-toulouse.fr</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-303623" status="VALID">
          <idno type="IdRef">026388278</idno>
          <idno type="ROR">https://ror.org/02vjkv261</idno>
          <orgName>Institut National de la Santé et de la Recherche Médicale</orgName>
          <orgName type="acronym">INSERM</orgName>
          <desc>
            <address>
              <addrLine>101, rue de Tolbiac, 75013 Paris</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.inserm.fr</ref>
          </desc>
        </org>
        <org type="regroupinstitution" xml:id="struct-441569" status="VALID">
          <idno type="IdRef">02636817X</idno>
          <idno type="ISNI">0000000122597504</idno>
          <idno type="ROR">https://ror.org/02feahw73</idno>
          <orgName>Centre National de la Recherche Scientifique</orgName>
          <orgName type="acronym">CNRS</orgName>
          <date type="start">1939-10-19</date>
          <desc>
            <address>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.cnrs.fr/</ref>
          </desc>
        </org>
        <org type="regrouplaboratory" xml:id="struct-552481" status="OLD">
          <idno type="RNSR">201622188C</idno>
          <orgName>Centre de Biologie Intégrative</orgName>
          <orgName type="acronym">CBI</orgName>
          <date type="start">2016-01-01</date>
          <date type="end">2025-01-01</date>
          <desc>
            <address>
              <addrLine>Université Paul Sabatier,18 Route de Narbonne, 31062 Toulouse</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://cbi-toulouse.fr/fr/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-217752" type="direct"/>
            <relation active="#struct-443875" type="indirect"/>
            <relation name="FR3743" active="#struct-441569" type="direct"/>
          </listRelation>
        </org>
      </listOrg>
    </back>
  </text>
</TEI>