Coadministration of coenzyme Q prevents rosiglitazone-induced adipogenesis in ob/ob mice - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue International Journal of Obesity Année : 2009

Coadministration of coenzyme Q prevents rosiglitazone-induced adipogenesis in ob/ob mice

Maria Carmen Carmona
  • Fonction : Auteur
Philippe Lefebvre
  • Fonction : Auteur
Bruno Lefebvre
Anne Galinier
Y. Jeanson
  • Fonction : Auteur
Katie Louche
  • Fonction : Auteur
S. Flajollet
  • Fonction : Auteur
Alain Ktorza
  • Fonction : Auteur
Catherine Dacquet
  • Fonction : Auteur
Louis Casteilla

Résumé

OBJECTIVE: The aim of this study is to determine the effect of coenzyme Q (Q) on ob/ob mice treated or not with thiazolidinedione (TZD). DESIGN AND MEASUREMENTS: Ob/ob mice were treated with Q, Rosiglitazone or a combination of both molecules for 13 days; physical and metabolic parameters as well as oral glucose tolerance test were assessed. mRNA expression of genes of energy dissipation and storage were measured by real-time PCR. RESULTS: Q treatment improved some metabolic parameters in ob/ob mice. Surprisingly, cotreatment with Rosiglitazone and Q improved metabolic parameters and prevented TZD increase in body weight and adiposity, mainly by increasing lipid oxidation in adipose tissue, reducing lipid synthesis and balancing adipokine gene expression. CONCLUSIONS: Our finding suggests that Rosiglitazone and coenzyme Q bitherapy could prevent the body weight gain associated with adipogenesis and could improve the clinical use of these compounds.
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Dates et versions

hal-00462260 , version 1 (09-03-2010)

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Citer

Maria Carmen Carmona, Philippe Lefebvre, Bruno Lefebvre, Anne Galinier, Alexandre Benani, et al.. Coadministration of coenzyme Q prevents rosiglitazone-induced adipogenesis in ob/ob mice. International Journal of Obesity, 2009, 33 (2), pp.204-11. ⟨10.1038/ijo.2008.265⟩. ⟨hal-00462260⟩
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