The aim of this study was to model the mechanical behavior of interfaces in masonry structures. In the first part, the characteristics of the materials and interfaces involved are determined experimentally. In the second part, a model based on the adhesion intensity is developed. This model can be used to describe the interfaces between mortar and full or hollow bricks and to describe the damage occuring in the mortar. The mechanical behavior predicted by this model is compared with previously obtained experimental data. The model is then tested in the case of some classical masonry structures (small walls, diagonal compression tests).