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Article Dans Une Revue FEBS Letters Année : 2010

Arc1p: anchoring, routing, coordinating.

Résumé

Accurate synthesis of aminoacyl-tRNAs (aa-tRNA) by aminoacyl-tRNA synthetases (aaRS) is an absolute requirement for errorless decoding of the genetic code and is studied since more than four decades. In all three kingdoms of life aaRSs are capable of assembling into multi-enzymatic complexes that are held together by auxiliary non-enzymatic factors, but the role of such macromolecular assemblies is still poorly understood. In the yeast Saccharomyces cerevisiae, Arc1p holds cytosolic methionyl-tRNA synthetase ((c)MRS) and glutamyl-tRNA synthetase ((c)ERS) together and plays an important role in fine tuning several cellular processes like aminoacylation, translation and carbon source adaptation.

Dates et versions

hal-00451322 , version 1 (28-01-2010)

Identifiants

Citer

Mathieu Frechin, Daniel Kern, Robert Pierre Martin, Hubert Dominique Becker, Bruno Senger. Arc1p: anchoring, routing, coordinating.. FEBS Letters, 2010, 584 (2), pp.427-33. ⟨10.1016/j.febslet.2009.11.037⟩. ⟨hal-00451322⟩

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