Article Dans Une Revue Journal of Peptide Science Année : 2010

Study of a lipophilic captopril analogue binding to angiotensin I converting enzyme

Résumé

HumanACE is a central component of the renin–angiotensin systemand amajor therapeutic target for cardiovascular diseases. The somatic form of the enzyme (sACE) comprises two homologous metallopeptidase domains (N and C), each bearing a zinc active site with similar but distinct substrate and inhibitor specificities. In this study, we present the biological activity of silacaptopril, a silylated analogue of captopril, and its binding affinity towards ACE. Based on the recently determined crystal structures of both the ACE domains, a series of docking calculations were carried out in order to study the structural characteristics and the binding properties of silacaptopril and its analogues with ACE.

Domaines

Dates et versions

hal-00449420 , version 1 (21-01-2010)

Identifiants

Citer

Georgios A. Dalkas, Damien Marchand, Jean-Claude Galleyrand, Jean Martinez, Georgios A. Spyroulias, et al.. Study of a lipophilic captopril analogue binding to angiotensin I converting enzyme. Journal of Peptide Science, 2010, 16, pp.91-97. ⟨10.1002/psc.1201⟩. ⟨hal-00449420⟩
99 Consultations
0 Téléchargements

Altmetric

Partager

  • More