Synthesis and evaluation of hybrid bis-cationic salts as antimalarial drugs
Résumé
A new series of hybrid bis-cations has been synthesized as potent antimalarial agents. These drugs share two different cationic heads derived from bis-thiazolium and bis-amidine salts. Structure-activity relationships has been defined and pointed out that the linker plays a prior role for antimalarial activity leading to compounds with significant oral activity.
| Origine | Fichiers produits par l'(les) auteur(s) |
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