Antitumor Effect of Plasma Treatment on U87 Glioma Xenografts: Preliminary Results
Résumé
This work was conducted to evaluate the potential antitumor effect of in vivo plasma treatment on U87-luc glioma tumor. A pulsed DBD with ms pulses at moderate power was used for treatment. Electrical analyses and spectroscopic measurements were realized to characterize plasma properties. We showed that plasma treatment was safe for mice. However reiterated long time plasma treatment (20 min, 3 consecutive days) produce a superficial burn. During plasma treatment, we observed an increase of subcutaneous temperature and a cutaneous skin pH reduction. After 5 d of plasma treatment, we observed a dramatically U87 bioluminescence decrease associated to a reduction of tumor volume in U87 glioma-bearing mice.