A serpin from the parasitoid wasp Leptopilina boulardi targets the Drosophila phenoloxidase cascade - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Developmental and Comparative Immunology Année : 2009

A serpin from the parasitoid wasp Leptopilina boulardi targets the Drosophila phenoloxidase cascade

Résumé

The insect phenoloxidase (PO) cascade is known to be tightly regulated by serine proteases and serine protease inhibitors of the serpin family. As a key component of the insect immune system, it is also suspected to be inhibited by several endoparasitoid wasps, insects that develop inside other arthropods as hosts. However, the underlying mechanisms of this inhibition are largely undescribed. Here, we report the characterization of a gene encoding a serpin, LbSPNy, highly expressed in the venom of the wasp Leptopilina boulardi (ISy type), and we show that either the venom or the recombinant LbSPNy inhibit the PO cascade in the hemolymph of Drosophila yakuba host larva. Altogether, our results identify the first serpin used as a virulence factor by a parasitoid wasp and show that it disrupts the activation pathway of the PO in the Drosophila host.

Domaines

Immunité innée

Dates et versions

hal-00435637 , version 1 (24-11-2009)

Identifiants

Citer

Dominique Colinet, Aurore Dubuffet, Dominique Cazes, Sébastien Moreau, Jean-Michel Drezen, et al.. A serpin from the parasitoid wasp Leptopilina boulardi targets the Drosophila phenoloxidase cascade. Developmental and Comparative Immunology, 2009, 33 (33), pp.681-689. ⟨10.1016/j.dci.2008.11.013⟩. ⟨hal-00435637⟩
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