Metabolic network visualization eliminating node redundance and preserving metabolic pathways - Archive ouverte HAL
Article Dans Une Revue BMC Biology Année : 2007

Metabolic network visualization eliminating node redundance and preserving metabolic pathways

Romain Bourqui
L. Cottret
Vincent Lacroix
D. Auber
P. Mary
  • Fonction : Auteur
M.-F. Sagot

Résumé

Background: The tools that are available to draw and to manipulate the representations of metabolism are usually restricted to metabolic pathways. This limitation becomes problematic when studying processes that span several pathways. The various attempts that have been made to draw genome-scale metabolic networks are confronted with two shortcomings: 1- they do not use contextual information which leads to dense, hard to interpret drawings, 2- they impose to fit to very constrained standards, which implies, in particular, duplicating nodes making topological analysis considerably more difficult. Results: We propose a method, called MetaViz, which enables to draw a genome-scale metabolic network and that also takes into account its structuration into pathways. This method consists in two steps: a clustering step which addresses the pathway overlapping problem and a drawing step which consists in drawing the clustered graph and each cluster. Conclusion: The method we propose is original and addresses new drawing issues arising from the no-duplication constraint. We do not propose a single drawing but rather several alternative ways of presenting metabolism depending on the pathway on which one wishes to focus. We believe that this provides a valuable tool to explore the pathway structure of metabolism.

Domaines

Autre [q-bio.OT]
Fichier principal
Vignette du fichier
2007_Bourqui_BMC-Systems-Biology_1.pdf (1.21 Mo) Télécharger le fichier
Origine Fichiers éditeurs autorisés sur une archive ouverte
Loading...

Dates et versions

hal-00434765 , version 1 (31-05-2020)

Identifiants

Citer

Romain Bourqui, L. Cottret, Vincent Lacroix, D. Auber, P. Mary, et al.. Metabolic network visualization eliminating node redundance and preserving metabolic pathways. BMC Biology, 2007, 1 - n°29, pp.1-19. ⟨10.1186/1752-0509-1-29⟩. ⟨hal-00434765⟩
138 Consultations
74 Téléchargements

Altmetric

Partager

More