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Article Dans Une Revue Angewandte Chemie International Edition Année : 2009

Solvent-Free Synthesis of Peptides

Résumé

A crush on sweetness ! A novel solvent-free methodology for the synthesis of peptides was developed: the coupling of an urethane protected N-carboxy anhydride (UNCA) of an aminoacid with another aminoacid derivative gave a protected dipeptide in very high yield under ball-milling conditions. The reaction is taking place in the solid state. This solvent-free synthesis was applied to the preparation of dipeptides and tripeptides, and exemplified in the preparation of Aspartame, in three steps, using the UNCA route, without any organic solvent and purification.
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Dates et versions

hal-00433100 , version 1 (04-01-2021)

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Valérie Declerck, Pierrick Nun, Jean Martinez, Frédéric Lamaty. Solvent-Free Synthesis of Peptides. Angewandte Chemie International Edition, 2009, 48, pp.9318-9321. ⟨10.1002/anie.200903510⟩. ⟨hal-00433100⟩
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