Ciguatoxin-induced catecholamine secretion in bovine chromaffin cells: Mechanism of action and reversible inhibition by brevenal. - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Toxicon Année : 2010

Ciguatoxin-induced catecholamine secretion in bovine chromaffin cells: Mechanism of action and reversible inhibition by brevenal.

Résumé

Ciguatoxin (P-CTX-1B) from the dinoflagellate Gambierdiscus toxicus, belongs to the family of polyether neurotoxins responsible for the neurological poisoning disorder ciguatera. Although it is the most widespread marine-borne disease affecting humans, there is no current FDA-approved treatment available except for symptomatic therapies. In this paper, we report that P-CTX-1B promotes catecholamine secretion from bovine chromaffin cells, an effect that is insensitive to concomitant activation of capacitative Ca(2+) entry. Moreover, we confirm that brevenal, a polyether from the dinoflagellate Karenia brevis, blocks P-CTX-1B-induced catecholamine secretion. This effect is partially reversible. Our results therefore raise the prospect of finding functional antagonists for P-CTX-1B that could be useful for the treatment of ciguatera.

Dates et versions

hal-00422943 , version 1 (08-10-2009)

Identifiants

Citer

Truong D Nguyen-Huu, César Mattei, Peter J Wen, Andrea J Bourdelais, Richard J Lewis, et al.. Ciguatoxin-induced catecholamine secretion in bovine chromaffin cells: Mechanism of action and reversible inhibition by brevenal.. Toxicon, 2010, 56 (5), pp.792-6. ⟨10.1016/j.toxicon.2009.08.002⟩. ⟨hal-00422943⟩

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