Convenient Solution-Phase Synthesis and Conformational Studies of Novel Linear and Cyclic ,-Alternating Peptoids
Résumé
The synthesis of a novel family of peptidomimetics composed of linear and cyclic α,β-alternating peptoids is described. Oligomers consisting of up to six peptoid residues (n = 1−3) were synthesized on large scale with use of an efficient iterative solution-phase method and longer oligomers (n = 4, 5) were obtained by the coupling of appropriately protected shorter oligomers. Preliminary conformational studies of these hybrid peptoids are reported.