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Article Dans Une Revue Biomacromolecules Année : 2002

Enzymatic degradation of block copolymers prepared from e-caprolactone and poly(ehtylene glycol)

Jonathan Mcgrath
  • Fonction : Auteur

Résumé

Block copolymers were prepared by ring-opening polymerization of e-caprolactone in the presence of monohydroxyl or dihydroxyl poly(ethylene glycol) (PEG), using Zn powder as catalyst. The resulting PCL-PEG diblock and PCL-PEG-PCL triblock copolymers were characterized by various analytical techniques such as NMR, SEC, DSC and X-ray diffraction. Both copolymers were semi-crystalline polymers, the crystalline structure being of the PCL-type. Films were prepared by casting dichloromethane solutions of the polymers on a glass plate. Square samples with dimensions of 10 x 10 mm were allowed to degrade in a pH = 7.0 phosphate buffer solution containing pseudomonas lipase. Data showed that the introduction of PEG blocks did not decrease the degradation rate of poly(e-caprolactone).
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Dates et versions

hal-00418013 , version 1 (17-09-2009)

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Citer

Suming Li, Jonathan Mcgrath. Enzymatic degradation of block copolymers prepared from e-caprolactone and poly(ehtylene glycol). Biomacromolecules, 2002, 3, pp.525-530. ⟨10.1021/bm010168s⟩. ⟨hal-00418013⟩
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