N-substituted bis-C-alkyloxadiazolones as dual effectors: efficient intermediates to amidoxines or amidines and prodrug candidates of potent antimalarials - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Bioorganic and Medicinal Chemistry Letters Année : 2009

N-substituted bis-C-alkyloxadiazolones as dual effectors: efficient intermediates to amidoxines or amidines and prodrug candidates of potent antimalarials

Résumé

A convenient route to N-substituted bis-C-alkylamidines possessing antiplasmodial activity and their oxadiazolone and amidoxime prodrug candidates, is described. These three families of compounds were available after a key N-alkylation step of the parent oxadiazolone 1a. Testing of the three compound classes in vitro and in vivo is also presented.
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hal-00413778 , version 1 (24-03-2022)

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Melissa Degardin, Sharon Wein, Thierry Durand, R. Escale, Henri Vial, et al.. N-substituted bis-C-alkyloxadiazolones as dual effectors: efficient intermediates to amidoxines or amidines and prodrug candidates of potent antimalarials. Bioorganic and Medicinal Chemistry Letters, 2009, 19 (17), pp.5233-5236. ⟨10.1016/j.bmcl.2009.07.001⟩. ⟨hal-00413778⟩
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