Novel amphiphilic poly(epsilon-caprolactone)-g-poly(L-lysine) degradable copolymers. - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Biomacromolecules Année : 2007

Novel amphiphilic poly(epsilon-caprolactone)-g-poly(L-lysine) degradable copolymers.

Résumé

As part of the search of novel degradable polymers, amphiphilic and cationic poly(epsilon-caprolactone)-g-poly(l-lysine) (PCL-g-PlL) copolymers have been synthesized following a grafting "onto" or a grafting "from" method both applied to a macropolycarbanionic PCL derivative. The first approach led to PCL-g-PZlL containing 36% of epsilon-caprolactone and 64% of N-epsilon-Z-l-lysine units, by reaction of activated poly(N-epsilon-Z-l-lysine) on the macropolycarbanion derived from PCL. The second route was based on the anionic ring opening polymerization of N-carboxyanhydride of N-epsilon-benzyloxycarbonyl-l-lysine initiated by the macropolycarbanion derived from PCL and led to a similar copolymer containing 45% of of epsilon-caprolactone and 55% of N-epsilon-Z-l-lysine units. After deprotection of the lysine units, PCL-g-PlL copolymers were obtained. These copolymers are water-soluble and form nanometric micelle-like objects with mean diameters between 60 and 500 nm in distilled water depending on the synthesis route.
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Dates et versions

hal-00413451 , version 1 (04-09-2009)

Identifiants

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Benjamin Nottelet, Abdeslam El Ghzaoui, Jean Coudane, Michel Vert. Novel amphiphilic poly(epsilon-caprolactone)-g-poly(L-lysine) degradable copolymers.. Biomacromolecules, 2007, 8 (8), pp.2594-2601. ⟨10.1021/bm700449c⟩. ⟨hal-00413451⟩
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