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Journal Articles Nature Reviews Immunology Year : 2009

Interleukin-22-producing innate immune cells: new players in mucosal immunity and tissue repair?

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Abstract

Mucosal tissues, lying at the interface with the external environment, are constantly challenged by microbial, physical and chemical assaults. To provide the necessary immune defence to such challenges, lymph nodes and Peyer's patches are formed in utero in response to inductive signals from lymphoid-tissue inducer (LTi) cells. As discussed in this Progress article, a series of recent reports has identified a population of interleukin-22-producing mucosal cells in the gut and tonsils that share features with both LTi cells (by expressing RORgammat) and natural killer cells (by expressing NKp46) and that might be involved in immunity and homeostasis in mucosal tissues.

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hal-00408427 , version 1 (30-07-2009)

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Eric Vivier, Hergen Spits, Tom Cupedo. Interleukin-22-producing innate immune cells: new players in mucosal immunity and tissue repair?. Nature Reviews Immunology, 2009, 9 (4), pp.229-34. ⟨10.1038/nri2522⟩. ⟨hal-00408427⟩

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