Cre/loxP-mediated chromosome engineering of the mouse genome. - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Handb Exp Pharmacol Année : 2007

Cre/loxP-mediated chromosome engineering of the mouse genome.

Y. Hérault

Résumé

Together with numerous other genome modifications, chromosome engineering offers a very powerful tool to accelerate the functional analysis of the mammalian genome. The technology, based on the Cre/loxP system, is used more and more in the scientific community in order to generate new chromosomes carrying deletions, duplications, inversions and translocations in targeted regions of interest. In this review, we will present the basic principle of the technique either in vivo or in vitro and we will briefly describe some applications to provide highly valuable genetic tools, to decipher the mammalian genome organisation and to analyze human diseases in the mouse.

Domaines

Immunologie
Fichier non déposé

Dates et versions

hal-00408334 , version 1 (30-07-2009)

Identifiants

Citer

V. Brault, V. Besson, L. Magnol, A. Duchon, Y. Hérault. Cre/loxP-mediated chromosome engineering of the mouse genome.. Handb Exp Pharmacol, 2007, 178, pp.29-48. ⟨10.1007/978-3-540-35109-2_2⟩. ⟨hal-00408334⟩

Collections

CNRS
26 Consultations
0 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More