Smart magnetic resonance imaging agents that sense extracellular calcium fluctuations - Archive ouverte HAL Access content directly
Journal Articles ChemBioChem Year : 2008

Smart magnetic resonance imaging agents that sense extracellular calcium fluctuations

Abstract

Image brain function: Gd3+ chelates linked to a modified EGTA moiety were prepared in order to respond to extracellular Ca2+ fluctuations in the brain. Upon interaction with Ca2+, they exhibit high and reversible relaxivity changes in buffered solution or in a model of the brain extracellular medium. These efficient Ca2+ magnetic resonance imaging sensors might open new perspectives in functional molecular imaging.

Dates and versions

hal-00407967 , version 1 (28-07-2009)

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Goran Angelovski, Petra Fouskova, Ilgar Mamedov, Santiago Canals, Éva Tóth, et al.. Smart magnetic resonance imaging agents that sense extracellular calcium fluctuations. ChemBioChem, 2008, 9 (11), pp.1729-34. ⟨10.1002/cbic.200800165⟩. ⟨hal-00407967⟩
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