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            <title xml:lang="en">MicroRNA-155 modulates the interleukin-1 signaling pathway in activated human monocyte-derived dendritic cells.</title>
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              <persName>
                <forename type="first">Maurizio</forename>
                <surname>Ceppi</surname>
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              <date type="whenReleased">2009-07-27 16:30:40</date>
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                <title xml:lang="en">MicroRNA-155 modulates the interleukin-1 signaling pathway in activated human monocyte-derived dendritic cells.</title>
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                    <forename type="first">Maurizio</forename>
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                  <affiliation ref="#struct-300707"/>
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                    <surname>Barras</surname>
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                  <idno type="halauthorid">232236-0</idno>
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                    <forename type="first">Walter</forename>
                    <surname>Reith</surname>
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                <author role="aut">
                  <persName>
                    <forename type="first">Manuel A</forename>
                    <surname>Santos</surname>
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                  <idno type="halauthorid">408449-0</idno>
                  <affiliation ref="#struct-60947"/>
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                  <persName>
                    <forename type="first">Philippe</forename>
                    <surname>Pierre</surname>
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                  <email type="domain">ciml.univ-mrs.fr</email>
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                <title level="j">Proceedings of the National Academy of Sciences of the United States of America</title>
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                  <publisher>National Academy of Sciences</publisher>
                  <biblScope unit="volume">106</biblScope>
                  <biblScope unit="issue">8</biblScope>
                  <biblScope unit="pp">2735-40</biblScope>
                  <date type="datePub">2009-02-24</date>
                  <date type="dateEpub">2009-02-04</date>
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              <classCode scheme="mesh">Adaptor Proteins, Signal Transducing</classCode>
              <classCode scheme="mesh">Base Sequence</classCode>
              <classCode scheme="mesh">RNA Processing, Post-Transcriptional</classCode>
              <classCode scheme="mesh">Signal Transduction</classCode>
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              <classCode scheme="mesh">Cells, Cultured</classCode>
              <classCode scheme="mesh">DNA Primers</classCode>
              <classCode scheme="mesh">Dendritic Cells</classCode>
              <classCode scheme="mesh">Humans</classCode>
              <classCode scheme="mesh">Interleukin-1</classCode>
              <classCode scheme="mesh">Lymphocyte Activation</classCode>
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            <abstract xml:lang="en">
              <p>In response to inflammatory stimulation, dendritic cells (DCs) have a remarkable pattern of differentiation (maturation) that exhibits specific mechanisms to control immunity. Here, we show that in response to Lipopolysaccharides (LPS), several microRNAs (miRNAs) are regulated in human monocyte-derived dendritic cells. Among these miRNAs, miR-155 is highly up-regulated during maturation. Using LNA silencing combined to microarray technology, we have identified the Toll-like receptor/interleukin-1 (TLR/IL-1) inflammatory pathway as a general target of miR-155. We further demonstrate that miR-155 directly controls the level of TAB2, an important signal transduction molecule. Our observations suggest, therefore, that in mature human DCs, miR-155 is part of a negative feedback loop, which down-modulates inflammatory cytokine production in response to microbial stimuli.</p>
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