Novel triazole derivatives as ghrelin analogue ligands of growth hormone secretagogue receptors - Archive ouverte HAL Accéder directement au contenu
Brevet Année : 2008

Novel triazole derivatives as ghrelin analogue ligands of growth hormone secretagogue receptors

Résumé

The present invention provides novel triazole derivatives as ghrelin analogue ligands of growth hormone secretagogue receptors according to formula (I) that are useful in the treatment or prophylaxis of physiological and/or pathophysiological conditions in mammals, preferably humans, that are mediated by GHS receptors. The present invention further provides GHS receptor antagonists and agonists that can be used for modulation of these receptors and are useful for treating above conditions, in particular growth retardation, cachexia, short-, medium- and/or long term regulation of energy balance; short-, medium- and/or long term regulation (stimulation and/or inhibition) of food intake; adipogenesis, adiposity and/or obesity; body weight gain and/or reduction; diabetes, diabetes type I, diabetes type II, tumor cell proliferation; inflammation, inflammatory effects, gastric postoperative ileus, postoperative ileus and/or gastrectomy (ghrelin replacement therapy).

Domaines

Chimie organique
Fichier non déposé

Dates et versions

hal-00407707 , version 1 (27-07-2009)

Identifiants

  • HAL Id : hal-00407707 , version 1

Citer

Jean-Alain Fehrentz, Aline Moulin, Jean Martinez, Luc Demange, D. B. D. Boeglin, et al.. Novel triazole derivatives as ghrelin analogue ligands of growth hormone secretagogue receptors. France, Patent n° : WO 2007/020013. 08-185. 2008. ⟨hal-00407707⟩
67 Consultations
0 Téléchargements

Partager

Gmail Mastodon Facebook X LinkedIn More