Apoptosis characterizes immunological failure of HIV infected patients - Archive ouverte HAL
Article Dans Une Revue Control Engineering Practice Année : 2009

Apoptosis characterizes immunological failure of HIV infected patients

Résumé

This paper studies the influence of apoptosis in the dynamics of the HIV infection. A new modeling of the healthy CD4+ T-cells activation-induced apoptosis is used. The parameters of this model are identified by using clinical data generated by monitoring patients starting Highly Active Anti-Retroviral Therapy (HAART). The sampling of blood tests is performed to satisfy the constraints of dynamical system parameter identification. The apoptosis parameter, which is inferred from clinical data, is then shown to play a key role in the early diagnosis of immunological failure.

Dates et versions

hal-00405318 , version 1 (20-07-2009)

Identifiants

Citer

Marie-José Mhawej, Brunet-François Cécile, Fonteneau Raphael, Damien Ernst, Virginie Ferré, et al.. Apoptosis characterizes immunological failure of HIV infected patients. Control Engineering Practice, 2009, 17, pp.798. ⟨10.1016/j.conengprac.2009.01.001⟩. ⟨hal-00405318⟩
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