Characterization of the acute inflammatory response after irradiation in mice and its regulation by interleukin 4 (Il4). - Archive ouverte HAL
Article Dans Une Revue Radiation Research Année : 2001

Characterization of the acute inflammatory response after irradiation in mice and its regulation by interleukin 4 (Il4).

Résumé

The aim of this study was to determine the effects of total-body irradiation of mice on the acute release of a panel of several mediators of inflammation and to evaluate the efficacy of Il4 in regulating these radiation-induced modifications. We studied the effects of exposure of C57BL6/J mice to 8 Gy gamma rays on the early release of cytokines, chemokines, acute-phase proteins, prostaglandins and corticosterone in either plasma or tissues compared to those observed after intraperitoneal injection of lipopolysaccharide from 1 h to 3 days after stimulation. During the characterization of the acute inflammatory response induced by radiation or lipopolysaccharide, we observed differences both in the type of mediators produced and in the time course of release. We next determined the anti-inflammatory potential of Il4 in this model of total-body irradiation. We found that Il4 was able to down-regulate the radiation-induced production of mediators of inflammation such as Gro1 (also known as KC, N51) in plasma and lung, corticosterone in blood, Il1b in lung, and prostaglandin E(2) in colon, suggesting the anti-inflammatory potential of Il4 in regulating the radiation-induced response.

Domaines

Neurobiologie
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Dates et versions

hal-00405252 , version 1 (20-07-2009)

Identifiants

  • HAL Id : hal-00405252 , version 1
  • PUBMED : 11352769

Citer

A. van Der Meeren, P. Monti, L. Lebaron-Jacobs, C. Marquette, P. Gourmelon. Characterization of the acute inflammatory response after irradiation in mice and its regulation by interleukin 4 (Il4).. Radiation Research, 2001, 155 (6), pp.858-65. ⟨hal-00405252⟩
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