Negative regulation of Caenorhabditis elegans epidermal damage responses by death-associated protein kinase. - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Proceedings of the National Academy of Sciences of the United States of America Année : 2009

Negative regulation of Caenorhabditis elegans epidermal damage responses by death-associated protein kinase.

Résumé

Wounding of epidermal layers triggers multiple coordinated responses to damage. We show here that the Caenorhabditis elegans ortholog of the tumor suppressor death-associated protein kinase, dapk-1, acts as a previously undescribed negative regulator of barrier repair and innate immune responses to wounding. Loss of DAPK-1 function results in constitutive formation of scar-like structures in the cuticle, and up-regulation of innate immune responses to damage. Overexpression of DAPK-1 represses innate immune responses to needle wounding. Up-regulation of innate immune responses in dapk-1 requires the TIR-1/p38 signal transduction pathway; loss of function in this pathway synergizes with dapk-1 to drastically reduce adult lifespan. Our results reveal a previously undescribed function for the DAPK tumor suppressor family in regulation of epithelial damage responses.

Domaines

Immunologie

Dates et versions

hal-00403260 , version 1 (09-07-2009)

Identifiants

Citer

Amy Tong, Grace Lynn, Vy Ngo, Daniel Wong, Sarah L Moseley, et al.. Negative regulation of Caenorhabditis elegans epidermal damage responses by death-associated protein kinase.. Proceedings of the National Academy of Sciences of the United States of America, 2009, 106 (5), pp.1457-61. ⟨10.1073/pnas.0809339106⟩. ⟨hal-00403260⟩

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