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Article Dans Une Revue Journal of Organic Chemistry Année : 2009

Supported Synthesis of Oxoapratoxin A

Résumé

A new synthesis of an oxazoline analogue of apratoxin A has been performed using a solid support. The efficient synthesis of the polyketide part on gram scale and the serine vinylogue is described. The use of chlorotrityl resin allowed the construction of two linear precursors corresponding to two different cyclization sites. This study describes a facile synthesis of analogues for future SAR studies of this potent antitumor compound.

Domaines

Chimie organique
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Dates et versions

hal-00396958 , version 1 (19-06-2009)

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Citer

Arnaud Gilles, Jean Martinez, Florine Cavelier. Supported Synthesis of Oxoapratoxin A. Journal of Organic Chemistry, 2009, 74, pp.4298-4304. ⟨10.1021/jo900583j⟩. ⟨hal-00396958⟩
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