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              <p>La majorité des lésions de l'ADN résulte des réactions cellulaires endogènes : c'est le concept « d'ennemi de l'intérieur ». La voie de réparation par excision de bases (BER) est critique dans la lutte contre ces lésions. La BER implique l'action successive et coordonnée de quatre enzymes dont une ADN glycosylase qui doit reconnaître et extraire de l'ADN une base modifiée parmi des milliers de bases intactes. La BER contribue à la stabilité du génome et retarde le processus de cancérogenèse, et aussi à la variabilité des gènes des immunoglobulines.</p>
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